中性粒细胞/淋巴细胞比值、血小板/淋巴细胞比值及平均血小板体积与系统性红斑狼疮活动度的相关性研究

Correlation of neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,mean platelet volume with disease activity in systemic lupus erythematosusi

目的探讨中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)及平均血小板体积(MPV)与系统性红斑狼疮(SLE)疾病活动度的相关性。方法选取2014年1月至2017年11月该院SLE住院患者100例(SLE组),根据SLE疾病活动指数(SLEDAI)评分将其分为活动组(SLEDAI评分大于10分,n=58)与非活动组(SLEDAI评分小于或等于10分,n=42)。另选取同期体检健康者47例作为对照组。检测NLR、PLR、MPV、血清补体C3(C3)、C反应蛋白(CRP)和红细胞沉降率(ESR),比较并分析各指标的相关性。结果与对照组比较,SLE组患者NLR、PLR升高,MPV降低,差异有统计学意义(P<0.01或P<0.05);经治疗后活动组SLE患者NLR、PLR、SLEDAI评分下降,MPV上升,差异有统计学意义(P<0.01或P<0.05)。SLE患者NLR、PLR和MPV均分别与SLEDAI评分、CRP、ESR及C3相关(NLR:r=0.779、0.622、0.684、-0.702;PLR:r=0.542、0.547、0.579、-0.618;MPV:r=0.236、-0.321、-0.347、0.318,P<0.05)。结论 NLR、PLR及MPV可以作为评估SLE疾病活动度的生物学指标。

Objective To evaluate the relationship between neutrophil-to-lymphocyte ratio （NLR）,platelet-to-lymphocyte ratio （PLR）,mean platelet volume （MPV） and disease-activity in patients with systemic lupus erythematosus （SLE）. Methods From January 2014 to November 2017,100 patients with SLE in the hospital were included into the SLE group,and other 47 healthy individuals undergoing physical examination were included into the control group.According to SLE disease activity index （SLEDAI）,the patients in the SLE group were further divided into the active group （SLEDAI score〉10 points, n =58） and non-active group （SLEDAI score≤10 points, n =42）.The NLR,PLR,MPV,C-reactive protein （CRP）,and erythrocyte sedimentation rate （ESR） were detected,and their relationships were analysed. Results Compared with the control group,the NLR and PLR in the SLE group were significantly increased,while the MPV had a significant decrease （ P 〈0.01 or P 〈0.05）.After treatment,NLR,PLR and SLEDAI score decreased promptly in parallel with an increase of MPV in the active group（ P 〈0.01 or P 〈0.05）.Furthermore,the NLR,PLR,and MPV of patients with SLE was correlated with SLEDAI score,CRP level,ESR and complement C3 （NLR： r =0.779,0.622,0.684, -0.702 ;PLR： r =0.542,0.547,0.579,-0.618;MPV： r =0.236,-0.321,-0.347,0.318, P 〈0.05）. Conclusion NLR,PLR and MPV can serve as biological indicators for the assessment of disease activity in patients with SLE.