白细胞介素17与溃疡性结肠炎相关性的Meta分析

A meta-analysis of the association between ulcerative colitis and interleukin-17

目的分析血清及肠黏膜组织白细胞介素17(IL-17)水平与溃疡性结肠炎(UC)的相关性。方法计算机检索PubMed、Web of Science、Embase数据库,中国期刊全文数据库(CNKI)、万方数据库,纳入所有定量检测UC患者血清或肠黏膜组织IL-17水平的病例对照试验,采用STATA12.0软件进行Meta分析。结果共纳入14项研究,其中UC患者642例(UC组),对照组368例。UC患者血清IL-17水平高于对照组,差异有统计学意义(SMD=1.06,95%CI:0.80~1.31,P=0.000)。UC患者血清IL-17水平与病情严重程度相关,重度组>中度组>轻度组,差异有统计学意义(中度vs.轻度:SMD=1.89,95%CI:0.80~2.98,P=0.001;重度vs.中度:SMD=1.71,95%CI:1.05~2.37,P=0.000;重度vs.轻度:SMD=4.13,95%CI:1.40~6.85,P=0.003)。患者肠黏膜标本IL-17水平高于对照组,差异有统计学意义(SMD=4.44,95%CI:2.93~5.96,P=0.000),但存在较大异质性(P<0.10,I2=85.3%)。结论血清、肠黏膜组织IL-17高表达可能与UC疾病发生、发展相关,其可作为诊断UC的潜在标记物。

Objective To investigate the relationships between interleukin-17 （IL-17） levels in serum and intestinal mucosal tissues and ulcerative colitis （UC）. Methods A literature search was conducted in several electronic databases,including PubMed,Web of Science,Embase,CNKI and WanFang Data.Case-control studies that involving quantitative data of serum/intestinal mucosa IL-17 levels in patients with UC were included.The meta-analysis was performed by using STATA12.0 software. Results A total of 14 studies were included,involving 642 cases of patients with UC and 368 controls.Serum level of IL-7 in patients with UC was higher than that in the control group,there was statistically significant difference （ SMD =1.06,95% CI ：0.80-1.31, P =0.000）.Moreover,the serum level of IL-17 was correlated with the severity of UC：severe group〉moderate group〉mild group,there were statistically significant differences （moderate vs . mild： SMD = 1.89,95% CI ：0.80-2.98, P =0.001;severe vs . moderate： SMD =1.71,95% CI ：1.05-2.37, P = 0.000 ;severe vs . mild： SMD =4.13,95% CI ：1.40-6.85, P =0.003）.The level of IL-7 in intestinal mucosal tissues of patients with UC was also higher than that in the control group,there was statistically significant difference （ SMD =4.44,95% CI ：2.93-5.96, P =0.000）,however,heterogeneity existed among the included studies （ P 〈 0.10, I 2=85.3%）. Conclusion The high expression levels of IL-17 in serum and intestinal mucosal tissues are related to the occurrence and development of UC,which indicates IL-7 could be used as a potential marker for the diagnosis of UC.