体质量指数与脑梗死的相关性研究

Study of relationship between body mass index and cerebral infarction

目的探讨体质量指数(BMI)对脑梗死的影响。方法以参加2006—2007年开滦集团职工健康查体的30~70岁在职及离退休职工101 510例作为研究对象,排除BMI缺失1 470例、脑梗死病史者2 171例、恶性肿瘤351例,最终纳入BMI统计分析者97 518例。依据BMI将总人群分3组:第1组:BMI<24kg/m^2;第2组:BMI 24~27.9kg/m^2;第3组:BMI≥28kg/m^2。采用COX比例风险模型分析BMI对脑梗死事件的风险比。结果脑梗死的发生率随着BMI增加呈上升趋势,分别为2.0%,3.1%,3.5%(趋势P<0.05)。Cox比例风险模型分析显示,与正常体质量者相比,超重者和肥胖者脑梗死风险比(HR)分别为41%,48%(P<0.05)。结论 BMI是脑梗死发生的独立危险因素。

Objective The effect of body mass index（BMI）on cerebral infarction was discussed.Methods In 2006--2007,101 510 participants took part in the health physical examination of the Kailuan Group,excluding the loss of BMI（n=1 470）,cerebral infarction（n=2 171）,malignant tumor（n=351）and finally 97 518 were included in the statistical analysis.According to BMI,the group was divided into three groups：the normal weight：BMI24 kg/m^2;overweight：BMI 24-27.9 kg/m^2;obesity：BMI≥28 kg/m^2.The risk ratio of BMI to cerebral infarction was analyzed using the COX proportional hazards model.Results The incidence of cerebral infarction increased with the increase of BMI,the result was 2.0%,3.1%,3.5%（P〈0.05）,respectively.The Cox proportional risk model analysis showed that compared with the normal weight group,the overweight and obesity groups were more likely to have a cerebral infarction,and the HR were 41% and 48% respectively（P〈0.05）.Conclusion BMI is an independent risk factor for cerebral infarction.