布地奈德对老年急性支气管炎患者临床症状及肺功能的影响

Effects of Budesonide on clinical symptoms and pulmonary function in patients with acute bronchitis

目的探讨布地奈德对急性支气管炎患者临床症状及肺功能的影响。方法选择我院急诊内科收诊的老年急性支气管炎患者150例,分为对照组74例及观察组76例。对照组患者接受常规方法治疗,观察组患者在常规治疗基础上氧化吸入布地奈德,两组患者连续治疗4周。观察及统计两组患者临床病症消失及住院、血氧饱和度(Sp O_2)恢复正常的时间。用肺功能检测仪对患者肺功能进行检测,检测内容包括:第1 s用力呼气容积(FEV1)、用力肺活量(FVC)、最大呼气峰流速百分比(PEF%);应用ELISA检测治疗前后不同时间内患者炎性因子水平;参考《呼吸科专病中医临床诊治》指南评价临床疗效。比较两组患者病症消失、住院、血氧饱和度(Sp O_2)恢复正常的时间、肺功能、炎性因子水平及临床疗效。结果观察组患者咳嗽、痰多、湿罗音、喘息、呼吸困难病症消失时间、住院及Sp O_2恢复正常时间均优于对照组(P<0.05)。治疗第10天(T2)、治疗第20天(T_3)时,观察组患者嗜酸性颗粒细胞、细胞总数与较对照组低(P<0.05);观察组IL-8、IL-6、TNF-α、NF-γ水平显著低于对照组(P<0.05)。观察组临床总有效率较对照组高(P<0.05)。结论常规疗法基础上加用布地奈德可显著改善急性支气管炎患者临床症状,优化肺功能,提高治疗效果,可推荐应用。

Objective To investigated the effect of Budesonide on the clinical symptoms and pulmonary function in patients with acute bronchitis. Methods Acute bronchitis patients admitted to internal emergency in our hospital were selected, and been divided into control group and observation group according to different treatment methods. Patients in the control group received conventional treatment, while the observation group received budesonide inhalation on the basis of conventional treatment. The two groups were treated for 4 weeks. The time of the clinical symptoms disappeared, hospitalization and blood oxygen saturation（SpO 2） normalized in the two groups was observed and recorded. The pulmonary function test instrument was used to detect the pulmonary function of the patients, including the forced expiratory volume in one second（FEV 1）, forced vital capacity （FVC） and maximum expiratory peak flow percentage （PEF%）; ELISA was used to detect the level of inflammatory factors in patients at different times before and after treatment. Clinical efficacy was evaluated by referring to Clinical Diagnosis and Treatment of Traditional Chinese Medicine for Respiratory Diseases . The clinical symptoms disappeared time, hospitalization time, blood oxygen saturation（SpO 2） normalized time, pulmonary function, inflammatory factor level and clinical efficacy were compared between the two groups. Results The symptoms disappeared time such as cough, phlegm, moist rales, wheezing, dyspnea, and the time of hospitalization and blood oxygen saturation（SpO 2） normalized in the observation group were shorter than those of the control group（ P 〈0.05）. At T 2 and T 3, the number of eosinophilic granular cells and the total number of cells in the observation group were lower than those in the control group （ P 〈 0.05 ）; The levels of IL-8, IL-6, TNF-α and NF-γ in the observation group were significantly lower than those in the control group （ P 〈0.05）. The total effective rate of the observation group was higher than that of the control group （ P 〈0.05）. Conclusion Budesonide combined with conventional therapy can significantly improve the clinical symptoms of patients with acute bronchitis, optimize the lung function and improve the therapeutic effect, which worthy of recommendation.