射频消融联合肝动脉化疗栓塞对原发性肝癌的疗效及对细胞因子的影响

Effect of radiofrequency ablation combined with transcatheter arterial chemoembolization on primary hepatocellular carcinoma and serum cytokines

目的研究射频消融联合肝动脉化疗栓塞对原发性肝癌疗效的影响。方法选取2015年1月至2016年9月本院收治的50例原发性肝癌患者,按照随机数字表法分为试验组和对照组,每组均为25例。对照组使用肝动脉化疗栓塞治疗,试验组采取射频消融联合肝动脉化疗栓塞治疗。对2组患者治疗期间的不良反应、治疗后2个月的临床疗效、术后1年复发率和生存率进行比较。观察2组患者治疗前后血清因子的情况。结果治疗后2个月,试验组谷氨酰转肽酶(GGT)、甲胎蛋白(AFP)明显低于对照组,组间比较差异有统计学意义(P<0.05)。试验组总的临床有效率明显高于对照组(P<0.05)。试验组1年复发率明显低于对照组(P<0.05),生存率明显高于对照组(P<0.05);试验组和对照组不良反应发生率差异无统计学意义(P<0.05)。结论原发性肝癌采取射频消融联合肝动脉化疗栓塞治疗,能明显改善患者的血清因子,降低复发率,提高生存率,是一种安全有效的治疗手段。

Objective To explore the effect of radiofrequency ablation combined with transcatheter arterial chemoembolization on primary liver cancer.Methods Fifty patients with primary hepatocellular carcinoma（HCC）were enrolled in our hospital from January 2015 to September 2016.These patients were divided into experimental group and control group according to the random number table method.There was 25 patients in each group.The patients in the control group were treated with hepatic arterial chemoembolization.The patients in the experimental group were treated with radiofrequency ablation and hepatic arterial chemoembolization.The adverse reactions during treatment,clinical efficacy after two months treatment,recurrence rate and survival rate postoperative 1 year were compared between two groups.The serum cytokines levels of the two groups were observed and compared before and after treatment.Results The levels of glutamyltranspeptidase（GGT）in the experimental group were significantly lower than those in the control group at 2 months after treatment（P〈0.05）.The alpha-fetoprotein（AFP）in the experimental group was significantly lower than that in the control group（P〈0.05）.There was significant statistical difference between two groups.The total clinical efficacy of the experimental group was significantly higher than that of the control group（P〈0.05）.The recurrence rate of the experimental group was significantly lower than that of the control group（P〈0.05）.The survival rate of the experimental group was significantly higher than that of the control group（P〈0.05）.There was no significant difference for the incidence of adverse reactions between two groups（P〈0.05）.Conclusion Radiofrequency ablation combined with transcatheter arterial chemoembolization for primary liver cancer could improve the serum cytokines,reduce the recurrence rate and improve the survival rate.It is a safe and effective therapeutic method.