特布他林联合BiPAP呼吸机治疗慢阻肺合并呼吸衰竭患者疗效分析

Efficacy analysis of Terbutaline combine with BiPAP in the treatment of chronic obstructive pulmonary disease with respiratory failure

目的分析特布他林联合无创通气呼吸机治疗慢阻肺合并呼吸衰竭的疗效及对患者心肺功能和血气分析指标的影响。方法选取2016年2月至2016年7月我院收治的慢阻肺合并呼吸衰竭患者96例作为研究对象,采用随机数字表法分为观察组与对照组,每组48例。对照组患者采用特布他林治疗,观察组在对照组治疗的基础上联合使用无创通气呼吸机治疗,比较两组患者的疗效、心肺功能和血气分析指标。结果治疗2周后,观察组患者的治疗总有效率(93.75%)显著高于对照组(77.08%),临床疗效显著优于对照组(P<0.05)。治疗后72 h,两组患者的第一秒用力呼吸量(FEV1)、用力呼气50%肺活量时流速(PEF50%)、肺总量(TLC)和射血分数(EF)均显著改善,观察组患者上述各指标均显著优于对照组,差异均有统计学意义(P<0.01);两组患者的pH、PaCO_2、PaO_2和SaO_2均显著改善,观察组患者各指标均显著优于对照组,差异均有统计学意义(P<0.05)。观察组患者的不良反应发生率(6.25%)略低于对照组(16.67%),差异无统计学意义(P>0.05)。结论特布他林联合Bi PAP呼吸机治疗慢阻肺合并呼吸衰竭患者疗效确切,可使患者心肺功能快速恢复,缓解呼吸困难症状。

Objective To analyze the efficacy of Terbutaline combine with non-invasive ventilator in the treatment of chronic obstructive pulmonary disease（ COPD） with respiratory failure and its effects on cardiorespiratory function and blood gas analysis.Methods 96 patients with chronic obstructive pulmonary disease combined with respiratory failure treated in our hospital from February 2016 to July 2016 were selected. They were randomly divided into observation group and control group,48 cases in each group. The control group were treated with Terbutaline. The observation group was treated with noninvasive ventilator on the basis of the treatment of the control group. The curative effect,cardiopulmonary function and blood gas analysis were compared between the two groups. Results After 2 weeks of treatment,the total effective rate of the observation group（ 93. 75%） was significantly higher than that of the control group（ 77. 08%）,and the clinical efficacy was significantly better than that of the control group（ P〈0. 05）. After 72 h of treatment,FEV1,PEF50%,TLC and EF in the two groups were significantly improved. All of the above indexes in the observation group were significantly better than those in the control group（ P〈0. 01）. The p H,PaCO_2,PaO_2 and SaO_2 of the two groups were significantly improved,and the indexes in the observation group were significantly better than those in the control group（ P〈0. 05）. The incidence of adverse reactions in the observation group（ 6. 25%） was slightly lower than that in the control group（ 16. 67%）,and the difference was not statistically significant（ P〉0. 05）. Conclusion The effect of the combined Bi PAP on the patients with COPD and respiratory failure is effective,which can make the patients recover quickly and relieve the symptoms of dyspnea.