慢性乙型肝炎患者血清免疫球蛋白水平变化及其在疾病诊治中的临床意义

Changes of Serum Immunoglobulin in Patients with Chronic Hepatitis B and Its Clinical Significance in Diagnosis and Treatment of Diseases

目的探讨慢性乙型肝炎患者血清免疫球蛋白水平变化及其在疾病诊治中的临床意义。方法对2016年1月~2017年5月我院收治的慢性乙型肝炎患者124例,按照疾病严重程度分为A组(轻型慢性乙型肝炎)、B组(重型慢性乙型肝炎)和对照组(同期健康体检者),三组均行血清免疫球蛋白(IgA、IgG、IgM)、凝血酶原时间及血清总胆红素水平测定,并进行各组检测指标水平比较。结果对照组IgA、IgG、IgM指标水平均低于A、B组,差异均有统计学意义(P<0.05);而且疾病好转组的IgA、IgG、IgM水平亦低于疾病无好转组,血清总胆红素低于无好转组,凝血酶原时间高于无好转组,差异均有统计学意义(P<0.05)。结论血清免疫球蛋白水平是反映慢性乙型肝炎患者病情严重程度的重要指标,在临床诊治中具有重要指导意义。

Objective To explore changes in patients with chronic hepatitis b serum immunoglobulin levels and its application in disease diagnosis and treatment effect. Methods Team in January 2016 May 2017 in our hospital treated 124 cases of patients with chronic hepatitis B,according to the severity of disease were divided into group A（light）of chronic hepatitis B,B group of chronic hepatitis B（heavy）.The control group was 60 health checkers in the same period.Serum immunoglobulin（IgA,IgG,IgM）,thrombin time and serum total bilirubin level were detected in all three groups. Results The control group IgA,IgG and IgM were smaller than group A and group B（P〈0.05）.The group IgA,IgG and IgM were lower than the unimproved group,the serum total bilirubin was lower than the unimproved group,the thrombin time was higher than the unimproved group（P〈0.05）. ConclusionThe changes of serum immunoglobulin levels play an important role in the diagnosis and treatment of chronic hepatitis b.