猪肺炎支原体主要保护性抗原的研究进展

Research Progress on Major Immunogenicity Proteins on Mycoplasma Hyopneumoniae

猪肺炎支原体(Mycoplasma hyopneumoniae,Mhp)是猪支原体肺炎(Mycoplsamal pneumonia of swine,MPS)的原发性病原,广泛流行于世界各地,对养猪业造成重大经济损失。MPS发病率高,死亡率低,主要导致猪慢性咳嗽,生长率降低,饲料转换率下降,体重增长缓慢。另外,MPS使宿主易感其他呼吸系统病原,从而造成继发感染。由于对具有良好免疫原性的Mhp特异性蛋白缺少深入研究,使得Mhp研究受到一定限制,从而影响了对MPS的控制。文章围绕Mhp主要黏附因子、膜蛋白及细胞质蛋白等主要保护性抗原蛋白予以综述,以期为MPS疾病诊断、监测和相关疫苗研究提供科学依据。

Mycoplasma hyopneumoniae（Mhp）,the primary pathogen of Mycoplsamal pneumonia of swine（MPS）,is highly prevalent worldwide and causes major economic losses to the pig industry.This disease is characterized by chronic coughing,poor growth rate,low feed conversion,and delayed weight gain,with high morbidity and low mortality.In addition,Mps increases the host＇s susceptibility to other respiratory pathogens and secondary infections.The lack of further study on immunogenic and specific proteins of Mhp restricted the development of Mhp to some extent,so it affected the control of MPS.In this research,the development of some major specific immunogenicity proteins including adhesion,membrane proteins and cytoplasmic protein research of Mhp were discussed,so as to provide scientific theoretical basis for the further research on the disease diagnosis,pathogen surveillance of Mhp,as well as the vaccine research.