胆结石患者血清CEA、CA19-9表达及与胆道炎症的关系探讨

Discussion on the Expression of Serum CEA and CA19-9 in Gallstone Patients and the Relationship with Biliary Tract Inflammation

目的观察胆结石患者血清癌胚抗原(CEA)、血清糖类抗原19-9(CA19-9)的表达情况,进一步分析二者与胆道炎症的关系。方法选取2015年6月至2016年6月我院收治的胆结石患者108例以及腹股沟疝患者50例,术前术后检测患者的血清CEA、CA19-9的表达水平,探讨血清CEA、CA19-9的表达对胆道炎症的影响。结果108例胆结石患者中,50例(46.30%)血清CEA、CA19-9的表达水平升高,与腹股沟疝患者比较,差异有统计学意义(P<0.05)。血清CEA、CA19-9表达升高者在治疗后水平均下降。结论胆结石患者的血清CEA、CA19-9表达水平会明显升高,能够作为临床判定胆道炎症的相关参考指标,对于诊断及治疗有重要价值。

Objective To observe the expression of serum eareinoembryonie antigen （CEA） and serum carbohydrate antigen 19-9 （CA19-9） in patients with gallstones, and to further analyze the relationship of CEA and CA19-9 with biliary tract inflammation. Methods＇ 108 cases of patients with gallstones and 50 cases of patients with inguinal hernia in our hospital from June 2015 to June 2016 were selected. The expression levels of serum CEA and CA19-9 were detected and analyzed preoperatively and postoperatively, to explore the influence of serum CEA and CA19-9 on biliary tract inflammation. Results＇ Among 108 patients with gallstone, 50 cases （46.30%） had increased expression levels of CEA and CA19-9, and the differences were statistically significant compared with patients with inguinal hernia （P 〈0.05）.The levels of CEA and CA19-9 decreased after treatment in patients with increased expression levels of CEA and CA19-9. Conclusions The levels of serum CEA and CA19-9 in patients with gallstones increase significantly, which can be used as reference indicators for clinical evaluation of biliary tract inflammation. Both indicators are of great value for the diagnosis and treatment.