未经治疗的抑郁症患者注意力及执行功能研究

Study of Attention and Executive Capacity in Untreated Depressed Patients

目的:检测未接受药物治疗的抑郁症患者注意力、执行功能状况及其与抑郁症状的关系。方法:抑郁症患者29例纳入抑郁组,健康体检者30例纳入对照组,2组分别进行计算机化的威斯康星卡片分类测验(WCST)和持续操作测验(CPT)检查,并用汉密尔顿抑郁量表(HAMD)对患者临床症状进行评估;比较2组执行功能的差别,并作相关分析。结果:抑郁组WCST的错误应答数、持续性错误数、完成第一分类所需应答数及CPT的遗漏性错误、反应时间标准误差、反应标准误差变异性、固着反应均高于对照组高(P<0.05);抑郁组WCST的错误应答数与HAMD评分呈正相关(r=0.44,P<0.05),CPT的替代性错误数与HAMD评分呈负相关(r=-0.41,P<0.05);抑郁组WCST的正确应答数与CPT的反应标准误差的变异性呈负相关(r=-0.46,P<0.05);抑郁组CPT的遗漏性错误与病程呈正相关(r=0.46,P<0.05)。结论:未服药的抑郁症患者存在执行功能和注意功能的损害,且与患者抑郁症状相关。

Objective： To examine the correlation between the symptoms of untreated depression patients and their attention and executive capacity. Methods： Twenty-nine untreated depression patients （depression group） and 30 healthy controls （control group） were enrolled. Wisconsin Card Sorting Test （WCST） and Continuous Performance Test （CPT） were applied to test attention and executive capacity. Hamilton Depression Rating Scale （HAMD） was used to evaluate the depression. The correlation between the symptoms of depression and attention and executive capacity was analyzed. Results： The results of total error, perseverative response, trials to complete first category in WCST and the results of omission, reaction standard error, variability of standard error, perseveration in CPT of cases in depression group were higher than those in control group （P〈0.05）. There was a positive correlation between error response （WCST） and HAMD scores （r=0.44, P〈0.05）. There was a negative correlation between commission （CPT） and HAMD scores （r=-0.41, P〈0.05）. There was a negative correlation between correct response （WCST） and variability of standard error （CPT） （r=-0.46, P〈005）. There was a positive correlation between omission （CPT） and course （r=0.46,P〈0.05）. Conclusion： Untreated patients with depressive disorder have defective attention and executive capacity due to the depressive symptoms.