唑来膦酸注射液联合乌司他丁治疗老年骨质疏松性髋部骨折患者的安全性及对认知功能的影响

The Safety and Cognitive Function Effect of Zoledronic Acid Injection Combined with Ulinastatin on in Elderly Patients with Osteoporotic Hip Fracture

目的:分析唑来膦酸注射液联合乌司他丁治疗老年骨质疏松性髋部骨折患者的安全性及对认知功能的影响。方法:从2013年10月-2016年2月笔者所在医院收治的老年骨质疏松性髋部骨折患者中选取100例,严格按照随机数字表法将其分为两组,两组患者均采用钙尔奇D进行常规治疗,在此基础上,给予对照组患者唑来膦酸注射液治疗,观察组于对照组基础上加用乌司他丁进行治疗,对比两组临床治疗效果。结果:相对于治疗前,两组患者治疗后四处骨密度均有所提高,且观察组均高于对照组(P<0.05);两组患者治疗期间均没有严重不良反应出现;观察组患者术后认知功能障碍发生率为6%,低于对照组的40%(P<0.05)。结论:唑来膦酸注射液联合乌司他丁治疗老年骨质疏松性髋部骨折患者的安全性高,不会对患者的认知功能造成严重影响,值得推广。

Objective： To analyze the effect of Zoledronic Acid Injection combined with Ulinastatin on the safety and cognitive function of elderly patients with osteoporotic hip fracture.Method： From October 2013 to February 2016, a total of 100 cases with hip osteoporotic fracture in our hospital were selected, they were divided into two groups strictly according to the random digital table method, two groups patients were treated with Cahrate D for routine treatment, on this basis, the control group received Zoledronic Acid Injection treatment, the observation group on the basis of the control group was treated with Ulinastatin, two groups of clinical curative effect was compared.Result： Compared with before treatment, after treatment of the two groups around the bone density increased, and the observation group were higher than the control group（P〈0.05）, the two groups of patients had no serious adverse reactions, in the observation group, the incidence of postoperative cognitive dysfunction was 6%, it was lower than 40% of the control group（P〈0.05）.Conclusion： Zoledronic Acid Injection combined with Ulinastatin in the treatment of elderly osteoporotic hip fracture is safe, and it will not seriously aftect the cognitive function of patients, so it is worth promoting.