吡拉西坦联合尼莫地平治疗对脑梗死后血管性痴呆临床效果及ADL、CDR评分观察

Observation on the Clinical Effect of Piracetam Combined Nimodipine on Vascular Dementia Following Cerebral Infarction and the Corresponding ADL Score and CDR Score

目的:观察吡拉西坦联合尼莫地平对脑梗死后血管性痴呆临床效果、日常生活能力量表(ADL)及痴呆程度量表(CDR)评分。方法:选取笔者所在医院2014年2月-2017年2月收治的104例脑梗死后血管性痴呆患者资料,依据临床采取的药物方案不同分为治疗组(52例)和对照组(52例);对照组行单纯尼莫地平治疗,治疗组联合吡拉西坦治疗,比较两组医治前后ADL、CDR、MMSE评分变化及用药安全性。结果:医治后,治疗组ADL、CDR、MMSE评分(20.14±5.33)、(1.01±0.52)、(26.71±3.23)分,均优于对照组的(28.34±7.62)、(1.52±0.66)、(20.58±3.72)分,差异均有统计意义(t=6.358 8、4.376 9、7.847 3,P<0.05);治疗组不良反应总发生率5.77%,显著低于对照组的21.15%,差异有统计学意义(X^2=5.282 5,P<0.05)。结论:脑梗死后VD行吡拉西坦联合尼莫地平可取得显著疗效,且安全性高,具一定临床应用及研究价值。

Objective：To observe the clinical effect of Piracetam combined Nimodipine on vascular dementia following cerebral infarction and the corresponding activities of daily living（ADL） score and clinical dementia rating（CDR） score.Method：A total of 104 patients with vascular dementia following cerebral infarction admitted into our hospital from February 2014 to February 2017 were selected and analyzed.The patients were divided into the treatment group of 52 cases and the control group of 52 cases according to different clinical medication program.The control group received Nimodipine treatment alone,while the treatment group received Piracetam combined Nimodipine treatment.The changes of ADL score,CDR score,mini-mental state examination（MMSE） score and drug safety before and after treatment in each group were compared.Result：The ADL score,CDR score,MMSE score after treatment were（20.14±5.33）,（1.01±0.52）,（26.71±4.23）points respectively of the treatment group,which were higher than（28.34±7.62）,（1.52±0.66）,（20.58±3.72）points of the control group,the differences were statistically significant（t=6.358 8,4.376 9,7.847 3,P〈0.05）;the total incidence of adverse reactions in the treatment group was 5.77%,which was lower than 21.15% in the control group,the difference was statistically significant（ X^2=5.282 5,P〈0.05）.Conclusion：Treating vascular dementia following cerebral infarction with Piracetam combined Nimodipine can achieve a significant treatment effect with high safety.Thus,it has certain clinical application and research value.