门诊以咽部异物感为主诉患者咽喉反流性疾病的流行病学调查

Epidemiological Investigation of Laryngopharyngeal Reflux Disease in Outpatients with Pharynx Foreign Body Sensation

目的:调查笔者所在医院耳鼻咽喉科门诊以咽部异物感为主诉患者咽喉反流性疾病(LPRD)的患病率及其相关因素。方法:对首诊于笔者所在科门诊共5 023例患者进行调查,对其中以咽部异物感为第一主诉的365例首诊患者进行问卷调查。采用反流症状指数(RSI)量表简化汉字版及反流体征指数(RFS)量表简体中文版进行调查,并分析各相关因素。结果:以咽部异物感为第一主诉患者占门诊就诊患者比例为7.27%。其中LPRD患者187例,占咽部异物感患者51.23%,占门诊所有患者3.72%。不同年龄段、不同职业及不同病程患病率比较,差异均有统计学意义(X^2=23.905、25.065、69.445,P<0.01)。而不同性别组、体重指数组患病率比较,差异均无统计学意义(X^2=0.017、1.632,P>0.05)。咽部异物感与胃灼热、胸痛、胃痛及持续清嗓有相关性(r=0.418、0.383);与红斑/充血及弥漫性喉水肿相关(r=0.608、0.576)。结论:年龄、职业和病程与LPRD相关;性别、体重指数与LPRD无关;咽部异物感与胃灼热、胸痛、胃痛及持续清嗓以及红斑/充血及弥漫性喉水肿关系最大。

Objective：To assess the prevalence of laryngopharyngeal reflux disease（LPRD） and its associated factors among patients presented to the otolaryngology clinic in our hospital with foreign body sensation in pharynx.Method：A total of 5 023 patients were surveyed during their first visit to our clinics.Among them,365 patients presented with foreign body sensation in pharynx as the first chief complaint,and their reflux symptoms were assessed using simplified Chinese version of reflux symptom index（RSI） and reflux finding score（RFS） questionnaires.The associated factors were analyzed.Result：Patients presented with foreign body sensation in pharynx as the first chief complaint constitue was 7.27% of all patients surveyed in the clinics.There were 187 patients who had LPRD,51.23% among patients with foreign body sensation in pharynx and 3.72% among all patients surveyed.There were significant differences in terms of age,occupation,and duration of the symptoms in patients with and without LPRD（ X^2=23.905,25.065,69.445,P〈0.01）.The differences in gender and BMI were not statistically significant（ X^2=0.017,1.632,P〉0.05）.The sensation of foreign body in the pharynx was associated with pharynx and heartburn/chest pain/stomachache,frequent throat clearing（r=0.418,0.383）,associated with erythema/hyperemia and diffuse larynx edema（r=0.608,0.576）.Conclusion：Age,occupation,and duration of symptoms has significant correlation with LPRD.Gender or BMI were not correlated with LPRD.The foreign body sensation in pharynx has highest correlation with heartburn/chest pain/stomachache,frequent throat clearing,erythema/hyperaemia,and diffuse laryngeal edema.