摘要
在N-甲基吡咯烷酮(NMP)促进下,布洛芬与SOCl_2在25℃酰氯化反应0.5h,再与加入的对氯苄醇在25℃成酯反应8h,得到布洛芬对氯苄酯。产物结构经~1H NMR,^(13) C NMR,IR和EI-MS等光谱确证。讨论了NMP促进布洛芬与SOCl_2反应生成酰氯的可能机理。该方法具有条件温和、操作简便和收率高等优点。
4-chlorobenzyl 2-（4-isobutylphenyl）propanoate were synthesized through acyl chlorination of ibuprofen with SOCl2 at 25 ℃ for 0.5 hin N-methyl pyrrolidone,followed by esterification with substituteat 25 ℃ for 8 h.The title compound was characterized by ^1H NMR,^13C NMR,IR and EI-MS.The proposed mechanism for the NMP-promoted of carboxylic acid with thionyl chloride was put forward.The main advantages of the developed methodology were mild reaction conditions,simple work-up procedure and short reaction time.
作者
祝显虹
林丽萍
曹波强
周安西
毛刘量
ZHU Xianhong1,LIN Liping2,CAO Boqiang1,ZHOU Anxi1,MAO Liuliang1(1.Key Laboratory of Applied Organic Chemistry,Higher Institutions of Jiangxi Province,Shangrao Normal University, Jiangxi Shangrao Jiangxi 334001 , China;2.The Middle School of Linhu, Yushan Jiangxi 334006, Chin)
出处
《上饶师范学院学报》
2018年第3期52-55,共4页
Journal of Shangrao Normal University
基金
上饶师范学院科研项目(201701)
关键词
N-甲基吡咯烷酮
布洛芬对氯苄酯
合成
N methyl pyrrolidone
4-chlorobenzyl 2-（4-isobutylphenyl）propanoate
synthesis
