基于肠道微生态探讨肥胖者的健康管理策略

Health Management Strategy for Obese Humans Based on Gut Microbiota

肥胖成为21世纪最具有挑战性的公共健康问题之一。近代医学研究表明肠道菌群失调与肥胖的发生密切相关,其作用机制主要为促进宿主对能量的吸收、影响肠粘膜通透性及食欲调控因子的分泌等。以肠道微生态作为新的切入点,从饮食、益生元与益生菌、粪菌移植、运动等方面研究肠道菌群结构变化与肥胖的关系,探讨通过影响肠道菌群预防和控制肥胖,可为肥胖人群提出有效健康管理策略。

Obesity is one of the most serious global public health challenges in 21 st century.Modern medical studies revealed that the occurrence of obesity is closely related to intestinal flora imbalance which might promote the host＇s energy absorption,influence the permeability of intestinal mucosa and the secretion of appetite regulation factors. In the aspects of diet regulation,probiotics and prebiotics,fecal bacteria transplantation,sports,etc.,we take intestinal microflora as a new breakthrough point,discuss the relationship between intestinal flora changes and obesity,and finally put forward an effective health management strategy for obese individuals.