FOXP3与TGF-β1在卵巢异位子宫内膜中的表达及意义

Expression and significance of FOXP3 and TGF-β1 in ovarian endometriotic tissues

目的探讨FOXP3和TGF-β1在卵巢异位内膜组织中的表达相关性及意义。方法采用免疫组织化学方法,检测40例卵巢异位子宫内膜、40例正常在位子宫内膜及40例正常卵巢组织中FOXP3和TGF-β1的表达情况及相关性。结果FOXP3在卵巢异位内膜组织中高表达,显著高于正常在位内膜(χ~2=22.55,P=0.000)及正常卵巢组织(χ~2=14.70,P=0.000);TGF-β1在卵巢异位内膜组织中多呈中度阳性、强阳性表达,显著高于正常在位内膜(χ~2=8.12,P=0.010)及正常卵巢组织(χ~2=4.34,P=0.037);FOXP3、TGF-β1在卵巢异位内膜组织中的表达具有正相关性(r=0.667,P=0.001)。结论卵巢异位内膜组织中,FOXP3、TGF-β1高表达且呈正相关,在两者的共同作用下,免疫状态被抑制,从而促进了内异症的发生及发展。

Objective To explore the expression and significance of FOXP3 and TGF-β1 expression in ovarian endometriotic tissues.Methods FOXP3 and TGF-β1 expression was detected in 40 cases of ovarian endometriotic tissues, 40 cases of normal endometrium tissues and 40 cases of normal ovarian tissues by immunohistochemistry（IHC）, and their relationship was investigated.Results FOXP3 showed high expression in ovarian endometriotic tissues, significantly higher than that of normal endometrium tissues（ χ 2 = 22.55 , P =0.000） and normal ovarian tissues（ χ 2 =14.70, P =0.000）. TGF-β1 showed moderate or strong positive expression in ovarian endometriotic tissues, and the expression was significantly higher than that in normal endometrium tissues（ χ 2 =8.12, P = 0.010 ） and normal ovarian tissues（ χ 2 =4.34, P =0.037）. Spearman correlation analysis showed that the expression of FOXP3 was positively correlated with the expression of TGF-β1 in ovarian endometriotic tissues（ r =0.667, P =0.001）.Conclusion The expression of FOXP3 and TGF-β1 in ovarian endometriotic specimen is high and shows positive correlation, suggesting that they have synergistic effect in the occurrence and development of EMS.