右美托咪定及其临床应用

Dexmedetomidine and Its Clinical Application

右美托咪定作为一种镇静-催眠药物,适用于全身麻醉的手术患者的镇静。右美托咪定还具有镇痛、抑制交感活性、无呼吸抑制等药理性质。右美托咪定可维持围术期循环稳定,抑制应激反应,减少麻醉剂及阿片类药物的用量和抗寒颤等作用,降低不良反应的发生率和病死率。自身疾病、环境因素以及对未来的忧虑等影响因素,使患者处于强烈的应激环境之中,应用右美托咪定是提高患者舒适性和安全性的一个重要组成部分。

Dexmedetomidine as a sedative-hypnotic drug has been widely used in patients undergoing operation with general anesthesia.Dexmetomidine also has pharmacological properties such as analgesia,inhibition of sympathetic activity and no respiratory inhibition.Dexmetomidine can maintain perioperative circulation stability,inhibit stress response,reduce the dosage of anesthetics and opiates,and prevent chills,and reduce the incidence of adverse reactions and the mortality.Patients are under intense stress due to their own disease,environmental factors and worries about the future,and the application of dexmetidine is an important component to improve the comfort and safety of the patients.