Ⅲ型胶原蛋白α1链基因rs1800255多态性与颅内动脉瘤发病关系的系统评价

Association of Type Ⅲ collagen alpha 1 rs1800255 polymorphism with intracranial aneurysm

目的系统评价Ⅲ型胶原蛋白α1(COL3A1)基因rs1800255 G>A多态性与颅内动脉瘤(IA)发病关系。方法截止2017年7月31日,联合检索NCBI PubMed、中国引文数据库(CNKI)及万方数据库等关于rs1800255G>A多态性与颅内动脉瘤发病相关病例-对照研究。应用Stata 12.0软件检测所纳入研究进行发表偏倚及异质性检验,以合并效应的OR及95%置信区间(95%CI)评估rs1800255 G>A多态性与颅内动脉瘤发病风险的关系。结果共6个研究数据,包含3 664例研究对象纳入研究。Meta合并分析结果显示,在显性遗传模型下,rs1800255 G>A多态性与颅内动脉瘤发病相关,与GG基因型比较,A等位基因携带者颅内动脉瘤的发病风险增高,整体合并效应的风险比[OR=1.68(95%CI:1.43,1.98)];隐性模型下,与GG+GA基因型比较,AA基因型可升高颅内动脉瘤的发病风险,合并效应的风险比[OR=1.62(95%CI:1.12,2.35)]。结论 COL3A1基因rs1800255 G>A多态性可能影响个体对颅内动脉瘤的易感性。

Objective To investigate the association between Type Ⅲ collagen alpha 1 rs1800255 polymorphism and intracranial aneurysm（IA） incidence. Methods Case-control studies between rs1800255 G 〉 A polymorphism and IA risk were searched in NCBI Pub Med, CNKI and Wanfang database. Stata 12.0 software was utilzied to detect the publication bias and heterogeneity across the data. Inclusion and exclusion criteria were formulated. Results Until July 31 st, 6 studies with 3,664 subjects were included. Meta-analysis showed that, in the dominant genetic model, rs1800255 G 〉 A polymorphism was significantly associated with IA. Compared with the GG genotype, A allele carrier experienced significantly increased risk of IA with pooled O^R equal to 1.68 and corresponding 95% CI as 1.43 to 1.98. Compared with the GG＋GA genotype, in the recessive genetic model, AA genotype subjects had significantly increased risk of IA with pooled O^R equal to 1.62 and corresponding 95% CI as 1.12 to 2.35. Conclusion COL3 A1 gene rs1800255 G 〉 A polymorphism may modify the susceptibility of person to IA.