血清Ghrelin水平与非创伤性股骨头坏死严重程度的相关性

Correlation of serum Ghrelin levels with disease severity in patients with non-traumatic osteonecrosis of femoral head:A preliminary study

目的探讨血清Ghrelin水平与非创伤性股骨头坏死(ONFH)严重程度的相关性研究。方法选取诊断为非创伤性ONFH的患者84例,并入选性别年龄匹配的健康对照组84例,ONFH影像学分级采用FICAT分期方法,采用Harris髋关节评分和VAS疼痛评分量表评价患者髋关节症状严重程度,采用酶联免疫吸附试验测定患者血清Ghrelin水平,并同时测定血清adiponectin和IL-33的水平,探讨Ghrelin水平与影像学分级、症状严重程度与血清生物学标志物的相关性。结果 ONFH患者血清Ghrelin水平显著低于正常健康对照组,血清Ghrelin水平与影像学进展呈负相关性和VAS评分呈负相关性,与Harris评分均呈显著相关性,此外血清Ghrelin与股骨头保护蛋白adiponectin呈正相关性,与骨坏死标记物IL-33呈负相关性。结论 ONFH患者血清Ghrelin水平与ONFH严重程度呈负相关,Ghrelin的低表达反映了ONFH的严重程度。

Objective The scope of this study was aimed to explore the relationship between serum Ghrelinlevels and disease severity in non-traumatic ONFH patients. Methods 84 non-traumatic ONFH patients and 84 healthy controls were enrolled for this study in our hospital. The radiographic progression was determined by FICATgrading system. The clinical severity was evaluated by visual analogue scale（VAS）,Harris hip scores（HSS）. Theserum APN concentrations were examined by enzyme-linked immunosorbent assay（ELISA）.Serum adiponectin andIL-33 levels were also examined. The relationship between serum Ghrelin levels and radiographic severity,clinicalseverity and biochemical indices were investigated. Results Serum Ghrelin levels were significantly lower inONFH patients than in healthy controls. Serum Ghrelin levels were negatively correlated with FICAT gradingsystem. In addition,Serum Ghrelin levels were also negatively related to VAS scores and positively associated withHSS scores,Last,Serum Ghrelin levels were positively with adiponectin levels and negatively correlated withIL-33 levels. Conclusion Serum Ghrelin levels in non-traumatic ONFH patients were negatively associated withthe disease severity. Decreased serum Ghrelin levels may reflect disease severity of non-traumatic ONFH.