多发性硬化与血清中维生素D水平的临床关系研究

Clinical relationship between vitamin D levels and multiple sclerosis system in serum

目的观察血清中维生素D水平与多发性硬化的临床关系。方法选取2014-05~2016-06医院诊治的患者复发型多发性硬化(RRMS)患者86例,设为观察组,选取同期入院健康体检者86例设为对照组。采用自拟问卷调查表对患者性别、年龄、维生素D水平等进行统计,评价血清中维生素D水平与多发性硬化的关系。结果观察组维生素D正常、不足率,显著低于对照组(P<0.05);观察组维生素缺乏率,显著高于对照组(P<0.05);86例多发性硬化患者中26例复发,60例未复发。单因素显示多发性硬化复发生率与家族史、入院时EDSS及病程差异无统计学意义(P>0.05);多发性硬化复发生率与血清维生素D水平及6个月后EDSS评分关系密切(P<0.05)。相关性研究显示多发性硬化与患者性别差异无统计学意义(P>0.05);血清维生素D与患者的年龄、病程等关系密切(P<0.05)。结论多发性硬化患者与血清维生素D水平存在相关性,且患者血清维生素D水平越低,年龄越大,病程越长,临床死亡率越高。

Objective To observe the relationship between serum levels of vitamin D and multiple sclerosis.Methods Thirty-six patients with relapsing multiple sclerosis（RRMS） who were diagnosed and treated in hospital from May 2014 to June 2016 were selected as the observation group.86 healthy patients who were hospitalized for the same period were selected as the control group.Self-designed questionnaires were used to measure the sex,age,and vitamin D levels of patients,and the relationship between serum vitamin D levels and multiple sclerosis was evaluated.Results The normal and insufficiency rate of vitamin D in the observation group was significantly lower than that in the control group（P〈0.05）;the vitamin deficiency rate in the observation group was significantly higher than that in the control group（P〈0.05）.Of 86 patients with multiple sclerosis,26 relapsed and 60 had no recurrence.There was no significant difference in the univariate recurrence rate and family history of multiple sclerosis,EDSS and course of disease at admission（P〈0.05）;multiple sclerosis recurrence rates were closely related to serum vitamin D levels and EDSS scores after 6 months（P〈0.05）.Correlation studies showed that there was no significant difference in the sex difference between multiple sclerosis and patients（P〈0.05）;serum vitamin D was closely related to the patient＇s age and course of illness（P〈0.05）.Conclusion Patients with multiple sclerosis are associated with serum vitamin D levels,and the lower the serum vitamin D level,the older the older the disease course and the longer the clinical mortality.