CK2在常见消化道肿瘤中的分子作用机制及潜在的治疗靶点

Molecular mechanism and potential therapeutic targets of CK2 in common gastrointestinal cancers

CK2基因在多种癌细胞中过度表达,与癌症的预后差密切相关。CK2涉及癌症发生和发展的众多方面,包括抑制癌细胞凋亡、调控细胞周期、DNA损伤应答及调节癌细胞内信号通路。现在有许多CK2抑制剂可用,并且已经显示其在体外、动物疾病模型和临床前模型中对各种癌症具有活性。并且其中一些正在临床试验中进行探索。现总结了当前CK2抑制剂在消化道肿瘤的研究进展,概括其抗癌活性及其相关细胞信号传导机制,提出CK2抑制剂在常见消化道肿瘤治疗中起到重要的作用,是一个潜在的治疗消化系统肿瘤的靶点。

The poor prognosis of various cancers is closely related to the overexpression of CK2 gene in various cancer cells. CK2 is involved in many processes of cancer incidence and development,including inhibiting cancer cell apoptosis,regulating cell cycle,DNA damage response and regulating cancer cell signaling pathways. A number of CK2 inhibitors are now available and have been shown to have activity against various cancers in vitro,Animal disease model and in pre-clinical models. Some of these inhibitors are now undergoing exploration in clinical trials as well. In this article,we summed up the research progress of CK2 inhibitors in gastrointestinal cancers,generalized the anticancer activity of CK2 inhibitors and their related cellular signaling mechanisms. These suggest that CK2 inhibitors play important role in common gastrointestinal tumors. CK2 inhibitors are the potential targets for treating gastrointestinal cancers.