血小板中生长因子在口腔种植中促进软组织与硬组织愈合的效应

Growth factors in platelets promote soft and hard tissue healing in oral implantology

背景:血液中含有的大量的生长因子及血小板,具有再生与修复的潜力,近年的研究证实,血小板中的生长因子对受伤后软硬组织的愈合有促进作用。目的:综述生长因子促进软硬组织愈合作用的研究进展及应用现状,为临床治疗提供可靠的依据。方法:通过文献调查法,检索万方数据库和中国知网和Pub Med在生长因子促进软硬组织愈合作用相关文献。中文检索词:血小板,生长因子,骨愈合,浓缩生长因子,种植;英文检索词:Platelet,growth factor,bone healing,concentrated growth factor,Planting。探讨生长因子的生物学特性,及其与软硬组织损伤修复的作用。结果与结论:当机体发出受伤信号后,受伤处血管首先会即刻收缩,其次组织会释放纤维蛋白基质与血小板以形成血栓止血,同时还有大量的生长因子来刺激细胞有丝分裂、活化及促进骨细胞的生长与新生血管的形成。就目前来看,基于此原理而衍生出的血小板浓缩技术在临床上对于软硬组织的愈合有明显的促进作用,应用效果反映良好,但仍存在浓缩生长因子的制造差异、有效成分、剂量、时间、最适浓度以及血小板的稳定性等问题。

BACKGROUND： A large number of growth factors in platelets hold the potential of regeneration and repair, which have been shown to promote soft and hard tissue wound healing.OBJECTIVE： To review the research progress and application status of growth factors in promoting the healing of soft and hard tissues, and to provide basis for clinical treatment. METHODS： Wan Fang, CNKI and Pub Med databases were searched for the articles concerning growth factors promoting the healing of soft and hard tissues. The keywords were ＂platelet, growth factor, bone healing, concentrated growth factor, planting＂ in Chinese and English, respectively. The biological characteristics of growth factors and the relationship with the repair of soft and hard tissues were discussed. RESULTS AND CONCLUSION： Once injury signaling is activated, contraction of the injured vessel will appear instantly, and then numerous fibrin and blood platelet productions form clots for hemostasis. Meanwhile, a variety of growth factors are released to stimulate cell mitosis andactivation, as well as promote osteogenesis and angiogenesis. Thereafter, the platelet concentrated technology is developed, and clinical experiments have indicated its positive role in the healing of soft and hard tissues. However, there are still some problems to be solved, such as the manufacturing differences, active ingredients, dosage, time, optimal concentration of concentrated growth factor, as well as the stabilityof blood platelets.