高血压患者尿微量白蛋白与冠状动脉病变相关性分析

The relationship of microalbuminuria and coronary artery disease in hypertension patients

目的探讨高血压(HT)患者尿微量白蛋白(UMA)与冠状动脉病变程度的相关性。方法将372例高血压患者按照选择性冠状动脉造影(CAG)结果分为4组:冠状动脉正常组;单支病变组;双支病变组(左主干病变相当于双支病变);三支病变组。比较4组患者UMA的变化,评价UMA对冠状动脉病变程度的预测价值。结果冠心病(CHD)各组UMA均明显高于冠状动脉正常组(P<0.01);UMA水平与冠状动脉病变程度成正相关,单支病变与双支病变、三支病变两两比较,UMA水平差异有统计学意义(P<0.01)。结论冠状动脉病变支数与UMA水平具有相关性,UMA增高是高血压患者冠心病的预测因子。

Objective To study the value of microalbuminuria（UMA） in predicting the extent of coronary artery lesions in patients with hypertension. Methods 372 hypertensive patients without diabetes mellitus who had taken coronary angiography or percutaneous coronary intervention were enrolled. All patients underwent UMA examination. All subjects were divided into four groups according the result of the CAG. The patients with normal CAG result were in the first group;The patients with single vessel lesion were in the second group;The patients with two vessel lesions were in the third group and the patients with three vessel lesions were in the fourth group. The applicability of UMA as the markers for predicting coronary heart disease（CHD）was analyzed. Results Compared with the coronary artery normol group,the value of UMA was higher than that of the coronary artery abnormol group（P〈0.01）. The level of UMA was correlated with the severity of coronary lesions. There were significant differences between single vessel disease and two or more vessel lesions（P〈0.01）. Conclusion With the increasing of UMA,there are more vessels lesion. UMA level is early pridictive factor in predicting the extent of coronary artery lesions.