老年缺血性脑卒中后疲劳与缺血性脑卒中血清白细胞介素1β、C反应蛋白、同型半胱氨酸水平的相关性分析

Correlation analysis of serum interleukin 1β,C reactive protein and homocysteine levels in elderly patients with ischemic stroke after fatigue and ischemic stroke

目的探讨老年缺血性脑卒中后疲劳与缺血性脑卒中血清白细胞介素1β(IL-1β)、C反应蛋白(CRP)、同型半胱氨酸(Hcy)水平的相关性。方法选取该院于2016年8月至2017年8月期间收治的老年缺血性脑卒中患者119例,按照疲劳严重度量表评分分为疲劳组40例与非疲劳组79例。所有研究对象均于清晨空腹抽取外周静脉血,分离血清,采用酶联免疫吸附试验法(ELISA法)测定血清IL-1β、CPR和Hcy水平。结果疲劳组日常生活活动能力(ADL)评分、Fugl-Meyer运动功能上肢和下肢评分低于非疲劳组和对照组,差异有统计学意义(非疲劳组:t=23.360 9、18.203 6、9.288 6,对照组:t=39.926 6、20.260 3、21.929 6,P<0.05);非疲劳组ADL评分、Fugl-Meyer运动功能上肢和下肢评分低于对照组,差异有统计学意义(t=23.021 4、6.831 9、16.810 3,P<0.05)。疲劳组血清IL-1β、CPR和Hcy水平高于非疲劳组和对照组,差异有统计学意义(非疲劳组:t=14.561 5、17.029 6、13.059 9,对照组:t=31.631 9、36.998 3、33.670 0,P<0.05);非疲劳组血清IL-1β、CPR和Hcy水平高于对照组,差异有统计学意义(t=23.866 0、28.774 4、26.135 4,P<0.05)。缺血性脑卒中后疲劳与IL-1β、CPR和Hcy呈线性正相关。结论老年缺血性脑卒中疲劳患者IL-1β、CPR和Hcy异常升高,且具有明显相关性。

Objective To investigate the correlation between serum interleukin 1β（IL-1β）,C reactive protein（CRP）and homocysteine（Hcy）levels in elderly patients with ischemic stroke after fatigue and ischemic stroke.Methods 119 elderly patients with ischemic stroke were selected from our hospital from August 2016 to August 2017.According to the fatigue severity scale,40 cases were divided into fatigue group and 79 cases in non fatigue group.The peripheral blood samples were taken from the fasting blood in early morning,and the serum levels of IL-1β,CPR and Hcy were determined by enzyme linked immunosorbent assay（ELISA）.Results The fatigue group ADL score,Fugl-Meyer motor function of upper and lower limbs were lower than those of non fatigue group and control group,the difference was statistically significant（non fatigue group：t=23.360 9,18.203 6,9.288 6,the control group：t=39.926 6,20.260 3,21.929 6,P〈0.05）;Non fatigue group ADL score,Fugl-Meyer motor function of upper and lower limbs score lower than the control group,the difference was statistically significant（t=23.021 4,6.831 9 16.810 3,P〈0.05）.Fatigue serum IL-1β,CPR and Hcy were higher than that in non fatigue group and control group,the difference was statistically significant（non fatigue group：t=14.561 5,17.029 6,13.059 9,the control group：t=31.631 9,36.998 3,33.670 0,P〈0.05）;Non fatigue group serum IL-1β,CPR and Hcy were higher than that of control group,the difference was statistically significant（t=23.866 0,28.774 4,26.135 4,P〈0.05）.There was a positive linear correlation between fatigue and IL-1 beta,CPR and Hcy in patients with ischemic stroke.Conclusion IL-1,CPR and Hcy levels in elderly patients with ischemic stroke fatigue were significantly elevated and it has obvious correlation.