急性冠状动脉综合征患者血清NT-proBNP、Hcy及hs-CRP水平变化及临床意义分析

NT-proBNP,Hcy and hs-CRP levels in patients with acute coronary syndromes and its clinical significance

目的分析急性冠状动脉综合征患者血清中N端B型脑钠肽前体(NT-proBNP)、同型半胱氨酸(Hcy)及超敏C反应蛋白(hs-CRP)水平情况及临床意义。方法选取2016年3月至2017年2月该院收治的200例急性冠状动脉综合征患者为研究对象,另选取同期体检健康者50例作为对照组,收集血清标本并分别采用电化学发光法、循环酶法及免疫透射比浊法检测血清NT-proBNP、Hcy及hs-CRP水平。结果急性冠状动脉综合征患者血清中NT-proBNP、Hcy及hs-CRP水平明显高于体检健康者,3种血清指标联合检测的阳性率可达91.50%;病情越严重、冠脉病变支数越多的急性冠状动脉综合征患者的血清NT-proBNP、Hcy及hs-CRP水平越高。结论 3种血清指标联合检测对急性冠状动脉综合征的临床诊断及治疗具有重要参考价值。

Objective To investigate the levels of N-terminal B-type brain natriuretic peptide（NT-proBNP）,homocysteine（Hcy）and high-sensitivity C reactive protein（hs-CRP）in serum of patients with acute coronary syndromes and clinical significance.Methods Twenty hundred patients with acute coronary syndromes were enrolled in our hospital from March 2016 to February 2017.Fifty patients with healthy subjects were selected as control.Serum samples were collected and immunocytochemistry Serum levels of NT-proBNP,Hcy and hs-CRP were measured by cyclic enzyme method and immunoturbidimetric turbidimetric assay.Results The levels of NT-proBNP,Hcy and hs-CRP in serum of patients with acute coronary syndromes were significantly higher than those of healthy subjects.The positive rate of serum test was 91.50%.The more serious the disease and the higher the number of coronary lesions The levels of NT-proBNP,Hcy and hs-CRP in patients with acute coronary syndromes were higher.Conclusion The combination of three serum markers coronary artery syndrome in the clinical diagnosis and treatment has important reference value.