植物J蛋白的生物学功能及其作用机制

Biological functions and action mechanisms of J-domain proteins in plants

J蛋白是一类含有J结构域或类J结构域、分子质量为40 k Da左右的蛋白。其主要作用是作为热激蛋白70s的辅助分子伴侣参与新生蛋白质的折叠、蛋白质正确构象的维持、蛋白质的转运、蛋白复合体的组装和解离等过程。鉴于近几年对植物J蛋白的生物学功能研究取得了长足进展,本文在扼要介绍植物J蛋白结构与分类的基础上,重点阐述了植物J蛋白的生物学功能及其分子作用机制,最后对该研究领域作了展望。

J-domain proteins,with a molecular mass of around 40 k Da,are a family of proteins that contain a signature J or J-like domain.Serving as co-chaperones of Hsp70 s,J-domain proteins play critical roles in nascent protein folding,maintaining of correct protein conformations,translocation of proteins across cellular membranes,degradation of misfolded proteins,and assembly and disassembly of protein complexes.Due to great progresses have been made in J-domain proteins of plants,this review briefly introduces the structure and classification of Jdomain proteins,mainly highlights their functional roles and action mechanisms in plants,and finally gives a prospect of this field.