阿司匹林联合低分子肝素治疗重度子痫前期的临床效果

Clinical effect of aspirin combined with low molecular weight heparin in treating severe preeclampsia

目的探讨阿司匹林联合低分子肝素治疗重度子痫前期的疗效。方法将我院2016年10月~2017年10月收治的重度子痫前期患者中抽取100例,按照入院号随机分为常规组与观察组,每组50例,常规组使用阿司匹林进行治疗,观察组使用阿司匹林联合低分子肝素进行治疗,治疗后比较两组患者的疗效、凝血功能及不良反应发生率。结果观察组患者的治疗疗效高于常规组,观察组PT、APTT高于常规组,FIB以及DD低于常规组,不良反应发生率低于常规组,差异均有统计学意义(P<0.05)。结论阿司匹林联合低分子肝素治疗重度子痫前期患者的疗效较好,可以改善妊娠结局,降低不良反应发生率,有很高的临床应用价值。

Objective To analyze the efficacy of aspirin combined with low molecular weight heparin in the treatment of severe preeclampsia. Methods 100 patients with severe preeclampsia who were admitted in our hospital from October 2016 to October 2017 were randomLy divided into the routine group and the observation group according to the hospital admission number,with 50 cases in each group.The routine group was treated with aspirin. The observation group was treated with aspirin combined with low molecular weight heparin. After treatment, the therapeutic efficacy, coagulation function, and incidence of adverse reactions were compared between the two groups of patients. Results The study showed that the treatment efficacy of the observation group was higher than that of the conventional group. The PT and APTT were higher in the observation group than those in the conventional group, and the FIB and DD were lower in the observation group than those in the conventional group. The incidence of adverse reactions in the observa- tion group was lower than that of the routine group, and the difference was statistically significant（P〈0.05）. Conclusion Aspirin combined with low molecular weight heparin is effective in the treatment of severe preeclampsia, which can improve pregnancy outcomes, reduce the incidence of adverse reactions and has a high clinical value.