头孢唑啉钠与妥布霉素联合应用对细菌性角膜溃疡的治疗效果观察

Observation on the therapeutic effect of cefazolin sodium combined with tobramycin on bacterial corneal ulcer

目的头孢唑啉钠与妥布霉素联合应用对细菌性角膜溃疡的临床疗效与应用价值。方法选取我院2014年9月~2016年10月期间收治的65例细菌性角膜溃疡患者,分为观察组与对照组。对照组所有患者均采用5%头孢唑啉钠眼药水与0.8%庆大霉素眼药水交替滴眼治疗;观察组所有患者均采用5%头孢唑啉钠眼药水与妥布霉素眼药水交替滴眼治疗。比较两组疗效及各项临床数据差异。结果两组疗效对比,观察组显著高于对照组(P<0.05);治疗后,观察组患者治疗时间与术后恢复所需时间明显优于对照组,组间差异显著(P<0.05)。结论头孢唑啉钠联合妥布霉素对细菌性角膜溃疡患者治疗效果显著,通过两组药物相互促进的药理作用可缩短治疗时间,且用药较为安全,有临床推广应用价值。

Objective To explore the clinical efficacy and application value of cefazolin sodium combined with tobramycin on bacterial corneal ulcer. Methods 65 patients with bacterial corneal ulcers who were admitted to our hospital from September 2014 to October 2016 were selected and divided into observation group and control group. All patients in the control group were given 5% cefazolin sodium eye drop and 0.8% gentamicin eye drop alternately. All patients in the observation group were given 5% cefazolin sodium eye drop and tobramycin eye drop alternately. The efficacy and the differences in various clinical data were compared between the two groups. Results The efficacy in the observation group was significantly higher than that in the control group （P〈0.05）; the treatment time and the time required for postoperative recovery in the observation group were significantly better than those in the control group after treatment, with significant differences between groups（P〈0.05）. Conclusion Cefazolin sodium combined with tobramycin has a significant clinical efficacy in the patients with bacterial corneal ulcers. Through the pharmacological action of mutual promotion of the two drugs, the treatment time can be shortened, and the use of drugs is safer, which has a clinical value of application and promotion.