C_2轴手性联芳基化合物催化四氢噻喃-4-酮和芳香醛的反应

Reaction of Tetrahydrothiopyran-4-one and Aromatic Aldehyde Catalysized by C_2 Axiallyl Chiral Biaryl Compounds

本文成功合成了4种C_2轴手性联芳基有机催化剂,并将其用于催化四氢噻喃-4-酮和芳香醛的反应。研究表明,当二氯甲烷作为溶剂、芳香醛和四氢噻喃-4-酮的摩尔比为1.2∶5、催化剂I的用量为10(mol)%、反应温度0℃、反应时间20h时,得到较高的产率(85%)及较好的立体选择性(86%)。

In this paper,four kinds of C2 axis chiral biaryl organic catalysts were successfully synthesized and used to catalyze the reaction of tetrahydrothiopyran-4-one and aromatic aldehydes. It is demonstrated that using dichloromethane as solvent,the molar ratio of aromatic aldehyde and tetrahydrothiopyran-4-one is 1. 2∶ 5,the dosage of catalyst is 10（ mol） %,the temperature and time of reaction are 0℃ and 20 h,the target products can be obtained with higher yield（ up to 85%） and better stereoselectivity（ up to 86%）.