LncRNA—HOTAIR与肿瘤侵袭转移

LncRNA-HOTAIR and Tumor Invasion and Metastasis

LncRNA—HOTAIR（LncHOTAIR）是一个全长为2158nt的长链非编码RNA，定位于hoxc基因座，它通过改变染色质状态和表观遗传修饰调控基因表达。LncHOTAIR作为调节肿瘤侵袭转移的重要分子越来越受到重视。已表明．HOTAIR在多种肿瘤中表达上调，与肿瘤的增殖、侵袭、转移以及肿瘤患者的预后有明显的相关性。其中，PRC2、EZH2、miR-34a、RBM38、OGF—OGFr、miR—1、CCND2、miR-148a、H1F-1α参与到HOTAIR调控网络。作为癌症相关的长链非编码RNA，HOTAIR是多种癌症转移和预后差的潜在的生物学标志物。阐明HOTAIR在肿瘤侵袭转移中的作用机制对于个体化精准治疗具有重要的理论意义。文章综述了HOTAIR在胃癌、肝癌、甲状腺癌、脑胶质瘤、胰腺导管腺癌、乳腺癌、非小细胞肺癌肿瘤侵袭转移过程中作用机制的研究进展。

LncRNA-HOTAIR （LncHOTAIR） is a 2158 nucleotides （nt） -long noncodingRNA located at hoxc locus and regulates gene expression by altering chromatin status and epigcnetic modifications. LncHOTAIR is drawing mounting attention as an important molecule regulating tumor invasion and metastasis. It has been shown that HOTAIR expression is up-regulated in a variety of tumors and bears a significant correlation with tumor proliferation, invasion, metastasis and progno-sis. PRC2, EZH2, miR-34 a, RBM38, OGF-OGFr, miR-1, CCND2, miR-148 a, HIF-1α areinvolved in the HOTAIR-regulating network. As a cancer-associated lncRNA, HOTAIR is a promis- ing biomarker for metastasis and prognosis in a wide array of cancers. It is of great theoretical signifi-cance to clarify the role of HOTA1R in tumor invasion and metastasis for achieving individualized precise treatment. This article reviews the advances in the studies on the role of HOTAIR in tumorinvasion and metastasis, including gastric, hepatic, thyroid cancer, glioma, pancreatic ductal adenocarcinoma, breast and non-small cell lung cancer.