内分泌干扰物对胰腺发育的影响及其机制研究进展

Effects of Endocrine Disrupting Chemicals on Pancreas Development and the Related Mechanisms

内分泌干扰物(endocrine disrupting chemicals,EDCs)可以从不同来源释放到环境中,近年来动物实验研究表明,多种EDCs能够破坏生命早期胰腺发育,增加成年期患代谢疾病的风险,但其潜在机制尚不完全清楚。本文总结了近年来EDCs对不同动物模型胰腺发育的影响,主要包括胰岛β细胞结构损伤、胰岛β细胞功能障碍、胰岛尺寸降低、胰岛畸形、次级胰岛形成延迟以及胰腺长度缩短等,并从转录因子、氧化应激以及表观遗传修饰等方面对其作用机制进行综述,以期为EDCs健康风险评估提供参考。

Endocrine disrupting chemicals（EDCs） are released into the environment from different sources. Recent experimental studies on animal models have shown that multiple EDCs can disrupt the pancreas development in early life and increase the risk of metabolic diseases in adulthood. However, the underlying mechanisms are not fully understood. This study focused on reviewing the effects of EDCs on pancreas development of different animal models. These effects mainly include islet β cell structure damage and dysfunction, decreased islet size, islet malformation, delayed secondary islet formation, and shortened pancreas length, etc. Further, mechanisms underlying these effects were reviewed in aspects of transcription factors, oxidative stress, and epigenetic modifications. This review will provide reference for the health risk assessment of EDCs.