两种常见耐药菌抗菌药物耐药情况的社会经济负担研究

Study on the social and economic burden of antiseptic resistance of two popular drug-resistant bacteria

目的以碳青霉烯类耐药肺炎克雷伯菌和头孢噻肟耐药大肠埃希菌为例，开展细菌耐药性的社会经济负担研究。方法引入伤残调整寿命年、健康效用值等指标，进行细菌耐药情况的社会经济学分析。结果经测算，2015年全国抗菌药物临床应用监测网187所成员单位住院患者因肺炎克雷伯菌、大肠埃希菌耐药造成的经济负担分别高达26049．89万元、35232．58万元；患者因疾病所致的伤残引起的健康寿命损失年分别为4658．02年、6634．97年。结论本研究尝试引人伤残调整寿命年、健康效用值等指标，提供了一种从疾病经济负担角度科学测算耐药性经济影响的思路。

Objective To study the socioeconomic burden of bacterial resistance incurred by taking carbapenem-resistant Klebsiella pneumoniae and eefotaxime-resistant Escheriehia coli as examples. Methods Such indexes as disability-adjusted life years and health utility values were used to conduct a socioeconomic analysis of drug resistance. Results The economic burden caused by Klebsiella pneumoniae and Escherichia coli resistance among inpatients of 187 members of the national antiseptic drug clinical application monitoring network in 2015 was as high as 260. 498 9 million yuan and 352. 325 8 million yuan respectively. The years of healthy life lost due to disability were 4 658.02 years and 6 346.97 years respectively. Conclusions This study introduced indexes such as disability-adjusted life years and health utility values, to scientifically innovate the measurement of the economic burden of drug resistance from the perspective of economic burden of diseases.