miR-195参与精神分裂症发病机制的研究进展

Research progress on role of miR-195 in schizophrenia

精神分裂症是一组病因未明的重性精神疾病,具有患病率较高、致残率较高和社会负担沉重等特点。研究表明,一些具有调节功能的RNA可能参与了包括精神分裂症在内的多种复杂疾病的发病机制,miRNA就是这样一类可抑制基因表达的非编码RNA。研究发现miRNA在精神分裂症患者大脑组织及外周血中均有显著差异表达。miR-195是miR-15/16/195/497家族的重要成员之一,也是在精神分裂症患者中差异表达的miRNA之一,提示了miR-195可能与精神分裂症的发病机制有关。该文就miR-195功能及其在精神分裂症中作用的研究进展进行综述。

Schizophrenia is a serious mental health illness with unknown etiology,high prevalence,high morbidity and heavy social burden.Some RNAs with regulatory functions may be involved in pathogenesis of many complex diseases,including schizophrenia.miRNAs are non-coding RNAs that negatively regulate gene expression.Differential miRNA expression has been found in the brain and peripheral blood of patients with schizophrenia.miR-195 is an important member of the miR-15/16/195/497 family.Previous studies have implicated that miR-195 may be involved in the pathogenesis of schizophrenia due to its differential expression.This review aimed to clarify the function of miR-195 and summarized the recent researches of miR-195 in schizophrenia.