硬胶囊中明胶溶解的研究进展

Review on Dissolution of Gelatin in Hard Capsule

从猪皮获得的明胶约占世界产量的50％，主要由通过酸浴和热处理的方法从皮肤中提取的胶原组成。明胶用于制造各种产品，特别是明胶硬胶囊（HGC）。明胶硬胶囊在水中具有不同的溶解度的问题一直是研究和讨论的课题。明胶的低溶出率的主要原因是在稳定凝胶网络和防止溶出的特定条件下，变性胶原链中有形成交联的倾向。由于明胶是从动物组织中提取的，可能含有胶原以外的分子（糖，脂质和其他蛋白质），这些分子可能与胶原链反应形成共价键，但这种生物聚合物的结构和组成还没有确定。本文综述了硬胶囊中明胶溶解的机制以及影响因素的研究进展，并试图找出影响HGC溶出度的原因。

Gelatin obtained from pig skins constitutes about 50% of world＇ s production and is mainly composed of col- lagen extracted from skin by acid bath and thermal treatment. The gelatin is used to make various products, especially hard gelatin capsules （HGC）. The issue of different solubility of gelatin hard capsules in water has been the subject of research and discussion. The main reason for low dissolution rate of gelatin is the tendency to form cross-links in the denatured collagen chains under specific conditions of stabilizing the gel network and preventing dissolution. As it is extracted from animal tissues, gelatin may contain molecules other than collagen （ sugars, lipids and other proteins） which may react with collagen chains to form covalent bonds. The structure and composition of this biopolymer have not yet been determined. Indeed, there are many differences from an article to another. Consequently, the reason for the dissolution of HGC is not yet clear.