逍遥散抗抑郁作用的研究现状

Research Status of Antidepressant Effect of Xiaoyaosan

抑郁症作为发病率逐年上升的一种常见精神系统疾病,除常见的化学药物治疗外,传统中医药的临床治疗应用一直受到关注。逍遥散作为经典的疏肝解郁名方,实验和临床研究均证实其具有良好抗抑郁作用。本文查阅近10年文献,发现逍遥散对不同抑郁样动物模型表现出良好抗抑郁作用,作用机制与干预单胺类神经递质水平、影响神经营养因子及相关通路、调节下丘脑-垂体-肾上腺（HPA）轴功能、抑制炎症反应及抗氧化等有关。查阅近5年文献,发现逍遥散及其衍生方单用、逍遥散与西药联用或与其他疗法联用,在临床上广泛用于各种抑郁症患者的治疗,疗效可靠、不良反应少。首次从拆方研究和组分研究2个角度对逍遥散抗抑郁作用的主要物质基础研究现状进行归纳,发现柴胡、当归、白芍、白术、薄荷是其发挥抗抑郁作用的主要药物基础。

Depression is a common psychiatric disorder with a rising incidence year by year. In addition to the common chemical drugs,the clinical application of traditional Chinese medicines has drawn much attention for depression. As a classic prescription for dispersing stagnated liver and relieving depression,Xiaoyaosan has a good antidepressant effect in experimental and clinical studies. The papers in last ten years were reviewed and the results showed that Xiaoyaosan had good antidepressant effect in the different depression-like animal model,and the antidepressant mechanism was related to modulation of monoamine neurotransmitter levels,effect on neurotrophic factors and the related pathways,regulation of hypothalamic-pituitary-adrenal（HPA） axis function,inhibition of the inflammatory response and anti-oxidation activity,et al. The papers of the nearly five years showed that Xiaoyaosan or its derivatives alone and Xiaoyaosan combined with western medicine or with other therapies were widely used in clinical treatment of various patients with depression,with reliable curative effect and few adverse reactions. The basic research status of Xiaoyaosan＇s antidepressant effect from the view of disassembled prescription and the components isolated from Xiaoyaosan was summarized for the first time,and the results showed that Bupleuri Radix, Angelicae Sinensis Radix, Paeoniae Radix Alba, Atractylodis Macrocephalae Rhizoma and Menthae Haplocalycis Herba were the main effective components for its antidepressant effect.