结核分枝杆菌生物被膜基质及潜在的药物靶点和治疗策略

Mycobacterium tuberculosis biofilm matrix and potential drug targets and treatment strategies

持留性是结核分枝杆菌产生耐药和复发的重要原因之一.分枝杆菌的持留性与生物被膜的形成密切相关,对生物被膜的研究将有助于新型抗结核药物的开发.细胞外多糖、蛋白、DNA和脂质是结核分枝杆菌生物被膜细胞外基质的重要组成成分.本文阐述了结核分枝杆菌生物被膜基质的组成成分及基于这些成分潜在的药物靶点和治疗策略,希望为结核分枝杆菌生物被膜基质的生物学功能的研究带来新的思考.

As one of the most successful pathogens, Mycobacterium tuberculosis adopts distinct mechanisms to survive drug exposure and to relapse. One example of such a mechanism is by generating persisters. Abundant evidence indicates that the generating persisters of Mycobacterium tuberculosis is influenced by their ability to grow as surface-associated multicellular communities called biofilms.Therefore, the research on the biofilm composition will contribute to the development of new antituberculosis drugs. The extracellular matrix of Mycobacterium tuberculosis biofilm is primarily composed of extracellular polysaccharide, as well as protein, DNA and lipid. This paper describes the composition of Mycobacterium tuberculosis biofilm matrix, based on which we discuss potential drug targets and treatment strategies, hoping to shed light on the biological function of Mycobacterium tuberculosis biofilm matrix.