白果内酯对脑缺血损伤保护作用的研究进展

Research progress on protective effect of bilobalide on cerebral ischemia injury

白果内酯是从银杏叶中提取到的倍半萜内酯,是银杏类制剂抗脑缺血作用的重要活性成分之一。白果内酯对脑缺血损伤保护的作用具有一定的量效关系和时效关系,作用机制主要包括:改善缺血后脑组织的能量代谢,抗炎症免疫损伤,抗兴奋性氨基酸神经毒性,抑制神经细胞的凋亡、促进神经元的增殖分化,并能减轻脑水肿的发生和脑部循环障碍,能全面针对脑缺血损伤的各种病理过程。简述白果内酯对脑缺血损伤保护的药效作用及其作用机制的研究进展。

Bilobalide is an important active ingredient of Ginkgo preparations against cerebral ischemia extracted from Ginkgo bilobaleaves. The protective effect of bilobalide on cerebral ischemic injury is dose-dependent and time-dependent. The main protective mechanism of bilobalide on cerebral ischemia injury is improving the energy metabolism of cerebral tissue after ischemia, anti-inflammatory immune injury, anti-excitatory amino acid neurotoxicity, inhibition of neuronal apoptosis, promoting neuronal proliferation and differentiation, alleviating encephaledema, and improving cerebral circulation disorder. Bilobalide can fully target various pathological processes of cerebral ischemia injury. This review explores research progress on the effect and mechanism of bilobalide on the protection of cerebral ischemia injury.