胚胎反复种植失败的免疫学预测指标

Immunological biomarkers of recurrent implantation failure

随着辅助生殖技术(ART)的发展,体外受精/卵胞质内单精子显微注射(IVF/ICSI)妊娠率不断提高,但是仍有部分患者经历多次胚胎移植失败。关于胚胎反复种植失败(RIF)的免疫学病因存在争议,本文就预测RIF的免疫学指标方面做一综述,同时进行深入探讨和归纳总结,以期为未来的基础研究和临床治疗提供参考。

With the rapid development of assisted reproductive technology, the pregnancy rates of in vitrofertilization/intracytoplasmic sperm injection（IVF/ICSI） have continued rising. However, there are still some patients suffering from recurrent implantation failure（RIF）. There are controversies about the immunological etiology of RIF. Therefore, in this article we presented an overview of RIF and provided an in-depth discussion and summary of the immunological mechanism of RIF, with a view to providing reference for future basic research and clinical management.