孕期外源物暴露致DNA甲基化异常与发育源性疾病的关系研究

Relation of abnormal DNA methylation induced by prenatal xenobiotics exposure and the development origins of disease

"健康与疾病的发育起源"(DOHaD)学说在近年来逐渐兴起,发育源性疾病的发生机制也受到关注。多项动物实验及流行病学调查研究显示,孕期外源物暴露致DNA甲基化异常在发育源性疾病发生机制中发挥着重要的作用。孕期根据时间顺序可分为三期,分别为孕早期、孕中期、孕晚期,不同时期的外源物暴露致DNA甲基化变化与发育源性疾病的关系也不尽相同。现就孕期外源物暴露致DNA甲基化变化与发育源性疾病的关系研究进行综述,为发育源性疾病的预防和治疗提供理论基础。

Recently, ＂Developmental Origins of Health and Disease（DOHaD）＂ theory has come into sight gradually. The mechanism of development origins of disease has also been concerned. A number of animal experiments and epidemiological studies indicated that DNA methylation aberrance induced by prenatal xenobiotics exposure plays a vital of importance role in development origins of disease. Gestation can be divided into three semesters, which are the first trimester, the second trimester, the third trimester. The relation of DNA methylation induced by different trimesters xenobiotics exposure and the development origins of disease are different. This review summarizes the relation of abnormal DNA methylation induced by prenatal xenobiotics exposure and the development origins of disease in order to provide theory base and new direction for the prevention and new treatment method of development origins of disease.