摘要
目的观察逍遥蒌贝胶囊对乳腺增生患者激素水平的调整作用。方法随机选取山西中医学院附属医院2016年1月—2017年3月就诊于乳腺科门诊的乳腺增生患者90例,随机分为观察组和对照组,各45例。观察组予以逍遥蒌贝胶囊治疗,对照组予以乳癖消片治疗。观察两组患者性激素水平,包括雌二醇(E_2)、孕酮(P)、促卵泡生成素(FSH)、黄体生成素(LH)、催乳素(PRL)的含量变化以及其临床疗效。结果两组患者治疗后治疗组总有效率为93.33%,对照组为75.56%,两组总有效率比较差异有统计学意义(P<0.05)。两组患者激素水平的比较,治疗后E_2、FSH、LH水平及E_2/P比值与本组治疗前比较,差异均有统计学意义(P<0.05)。治疗组治疗后E_2、P、PRL水平及E_2/P比值与对照组治疗后比较,差异均有统计学意义(P<0.05)。结论逍遥蒌贝胶囊能有效降低乳腺增生患者的E_2、PRL水平,升高P水平,调整雌孕激素失衡状态,减少雌激素对乳腺组织的不良刺激,乳腺增生的发生,临床疗效显著。
Objective To observe the adjusting effect of Xiaoyaoloubei Capsule on the level of hormone of patients with hyperplasia of mammary glands. Method A total of 90 cases of patients with breast hyperplasia,were randomly selected,in the outpatient department of Affiliated hospital of Shanxi University of Traditional Chinese medicine from January 2016 to March 2017. And they were randomly divided into the observation group and the control group,with 45 cases in each group. The observation group received the treatment of Xiaoyaoloubei Capsule while the control group received the treatment of Rupixiao Tablets. The levels of sex hormones,including estradiol2( E2),progesterone( P),follicle stimulating hormone( FSH),luteinizing hormone( LH),prolactin( PRL),and clinical efficacy were observed in two groups of patients.Results After treatment,the effective rate of the treatment group was 93. 33% and the control group was 75. 56%. There was significant difference between the two groups( P〈0. 05). As for the two groups of patients with hormone levels,after treatment,E2,FSH,LH levels and E2/P ratio were compared with the group before treatment. The differences were statistically significant( P〈0. 05). After treatment,the levels of E2,P,PRL and E2/P in the treatment group were significantly different from those in the control group after treatment( P〈0. 05). Conclusion Xiaoyaoloubei Capsule can effectively reduce breast hyperplasia in patients with E2 and PRL levels,elevate P levels,adjust the E2/P ratio abnormal,reduce the adverse effects of estrogen on breast tissue and reduce the occurrence of mammary gland hyperplasia. The clinical curative effect is remarkable.
作者
贾颖
王友球
JIA Ying;WANG You - qiu(Shanxi University of Traditional Chinese Medicine,Jinzhong ShanXi 030619)
出处
《世界中西医结合杂志》
2018年第6期820-823,共4页
World Journal of Integrated Traditional and Western Medicine
基金
山西省科技厅攻关项目(20140313009-9)
关键词
逍遥蒌贝胶囊
乳癖消片
性激素
Xiaoyaoloubei Capsule
RupixiaoTablets
Sex Hormone