多囊卵巢综合征体重指数与临床特征的相关性分析

Correlation of Clinical Features and Body Mass Index in Patients with Polycystic Ovary Syndrome

目的探索不同体重指数的多囊卵巢综合征(PCOS)患者血清性激素及糖脂代谢水平。方法 323例PCOS患者根据体重指数分为3组,由专业人员对PCOS患者进行腰围、臀围的测量及多毛、痤疮、黑棘皮的记录,并于患者自然月经周期或孕激素撤退出血的第3~5天空腹测血清性激素、糖脂代谢水平。结果 323例PCOS患者根据体重指数(BMI)分为3组:A组(BMI<23kg/m^2)、B组(23kg/m2≤BMI<25kg/m^2)、C组(BMI≥25kg/m^2),构成比分别为10.84%、34.67%、54.49%;腰围、臀围、腰臀比(WHR)在不同BMI中比较差异均有统计学意义(P<0.05),且腰围、臀围、WHR与BMI呈正相关。黑棘皮发生率在不同BMI组中差异有统计学意义;PCOS患者血清性激素水平在不同BMI组中比较,差异有统计学意义(P<0.05),FSH、LH和SHBG与BMI呈负相关,E_2与BMI呈正相关;糖脂代谢指标在不同BMI PCOS患者中代谢水平不同,其中TG、TC、LDL、FPG、FINS和HOMA-IR均与BMI呈正相关。结论不同BMI PCOS患者表现出血清性激素及糖代谢的差异,且FSH、LH、SHBG、E2、TG、TC、LDL、FPG、FINS水平和HOMA-IR指数均与BMI相关。

Objective to explore the levels of serum sex hormones and glucose and lipid metabolism in patients with polycystic ovary syndrome （PCOS） with different body mass index. Methods Totally 323 cases of PCOS were divided into three groups according to body mass index.Professional persong measured the waist circumference, hip circumference and recorded hirsutism, acne, acanthosis. In natural menstrual cycle or progesterone withdrawal bleeding 3-5 days, we measured fasting serum sex hormones and glucose and lipid metabolism. Results Totally 323 patients with PCOS were divided into three groups according to body mass index：group A （BMI〈23kg/m2）, group B （23kg/m22）, group C （BMI ≥ 25kg/m2）, accounted for 10.84%, 34.67%, 54.49%; waist and hip circumference, WHR comparison in different BMI group were statistically significant （P〈0.05）. Waist circumference, hip circumference, WHR was positively correlated with BMI. The occurrence of acanthosis is different in three BMI group. In patients of different BMI with PCOS, there were differences in sex hormone levels, which had statistical significance （P〈0.05）. BMI was negatively related to LH and SHBG, and FSH, E2 was positively associated with BMI; Glucose and lipid metabolism in different BMI PCOS in patients with different metabolic level（P〈0.05）. TG, TC, LDL, FPG, FINS and HOMA-IR were positively correlated with BMI. Conclusion patients with different BMI have different sex hormones and glucose metabolism. FSH,LH,SHBG,E2,TG,TC,LDL,FPG,FINS and HOMA-IR index are correlated with BMI in patients with PCOS.