期刊文献+

3%氯化钠对重症手足口病患儿炎性因子的影响

下载PDF
导出
摘要 目的观察3%氯化钠治疗重症手足口病的临床疗效及其对外周血炎性因子的影响。方法将医院收治的重症手足口病90例患儿随机分为观察组及对照组各45例。对照组予以抗病毒、降颅压等治疗,观察组在此基础上加用3%氯化钠。比较2组的临床疗效,同时采集并比较2组患儿治疗前后外周静脉血白介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平的变化。结果观察组总有效率为95.56%显著高于对照组的82.22%,差异有统计学意义(χ2=4.050,P<0.05)。治疗前2组患儿血清IL-6、TNF-α水平比较差异无统计学意义(P>0.05);治疗7 d后,2组患儿的血清IL-6、TNF-α水平均较治疗前下降,且观察组下降更明显,差异均有统计学意义(P<0.05)。结论 3%氯化钠能有效减轻重症手足口病患儿的炎性反应,提高临床疗效,值得临床推广应用。
出处 《临床合理用药杂志》 2018年第22期74-75,共2页 Chinese Journal of Clinical Rational Drug Use
  • 相关文献

参考文献9

二级参考文献116

  • 1朱启镕,王晓红,王建设.婴儿肝病综合征诊治修订方案[J].中华传染病杂志,2004,22(5):357-357. 被引量:74
  • 2Yan Ding,Lei Zhao,Hong Mei,Zhi-Hua Huang,Shu-Ling Zhang.Alterations of biliary biochemical constituents and cytokines in infantile hepatitis syndrome[J].World Journal of Gastroenterology,2006,12(43):7038-7041. 被引量:19
  • 3黄子通,常瑞明.创伤性休克的液体复苏进展[J].中华急诊医学杂志,2007,16(1):108-109. 被引量:20
  • 4Kolsen-Petersen JA. Immune effect of hypertonic saline: fact or fiction? [J]. Acta Anaesthesiol Scand,2004,48(6):667-678.
  • 5Steppich B, Dayyani F, Gruber R, et al. Selective mobilization of CD14( + )CDI6( + ) monocytes by exercise[J]. Am J Physiol Cell Physiol, 2000,279 (3) :578-586.
  • 6Maddali S, Stapleton PP, Freeman TA, et al. Neuroendocrine responses mediate macrophage function after trauma [ J]. Surgery, 2004, 136 (5): 1038-1046.
  • 7Wade CE, Kramer GC, Grady JJ, et al. Efficacy of hypertonic 7.5% saline and 6% dextran-70 in treating trauma: a meta-analysis of controlled clinical studies[J]. Surgery, 1997,122(3) :609-616.
  • 8Qureshi AI, Suarez JI, Bhardwaj A, et al. Use of hypertonic (3%) saline/acetate infusion in the treatment of cerebral edema: Effect on intracranial pressure and lateral displacement of the brain[J]. Crit Care Med, 1998, 26(3) :440-446.
  • 9Munar F, Ferrer AM, de Nadal M, et al. Cerebral hemodynamic effects of 7.2% hypertonic saline in patients with head injury and raised intracranial pressure[J].J Neurotrauma, 2000, 17 ( 1 ) : 41-51.
  • 10Schwarz S, Georgiadis D, Aschoff A, et al. Effects of hypertonic (10%) saline in patients with raised intracranial pressure after stroke[J]. Stroke, 2002, 33 ( 1 ) : 136-140.

共引文献494

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部