桉柠蒎对慢性阻塞性肺疾病急性加重期患者肺功能及氧化应激的影响

Effect of Eucalyptus on Pulmonary Function and Oxidative Stress in Patients with Acute Exacerbation of Pulmonary Chronic Obstructive Pulmonary Disease

目的:探讨桉柠蒎对慢性阻塞性肺疾病急性加重期(AECOPD)患者肺功能及氧化应激的影响。方法:选取2010年9月-2017年6月在我院进行治疗的AECOPD患者126例,采用乱数表法将所有患者分为对照组和研究组各63例。对照组给予盐酸氨溴索口服溶液治疗,研究组给予桉柠蒎肠溶软胶囊治疗,比较两组患者的临床疗效及治疗前后的用力肺活量(FVC)、第1秒用力呼气容积(FEV1)以及第1秒用力呼气容积占预计值百分比(FEV%)、丙二醛(MDA)、8-异构前列腺素(8-isoprostane)水平,观察两组患者治疗过程中不良反应发生率。结果:研究组患者的总有效率为95.24%,高于对照组的82.54%(P<0.05)。两组患者治疗前的FVC、FEV1、FEV%比较无统计学差异(P>0.05),治疗28d后两组患者的FVC、FEV1、FEV%均明显上升,且研究组的FVC、FEV1、FEV%高于对照组(P<0.05)。两组患者治疗前的MDA、8-isoprostane比较无统计学差异(P>0.05),治疗28d后两组患者的MDA、8-isoprostane明显下降(P<0.05),治疗28d后研究组的MDA、8-isoprostane低于对照组(P<0.05)。对照组不良反应发生率为7.94%(5/63),与研究组的6.35%(4/63)相比,差异无统计学意义(P>0.05)。结论:桉柠蒎可明显改善AECOPD患者的肺功能和氧化应激,具有较好的临床疗效,且不良反应率低,值得临床推广应用。

Objective： To investigate the effect of eucalyptus on pulmonary function and oxidative stress in patients with acute exacerbation of pulmonary chronic obstructive pulmonary disease（AECOPD）.Methods： A total of 126 patients with AECOPD,who were treated in Anhui NO.2 Provincial People＇s Hospital from September 2010 to June 2017,were selected and randomly divided into control group（n=63） and study group（n=63）.The control group was treated with Ambroxol Hydrochloride Oral Solution,the study group was given eucalyptol linonene pinene enteric soft capsule.The clinical efficacy and the forced vital capacity（FVC）,forced expiratory volume in 1 second（FEV1）,the forced expiratory volume in one second（FEV%）,the malondialdehyde（MDA） and the 8-heterogeneous prostaglandin（8-isoprostane） level before and after treatment were compared between the two groups.The incidence of adverse reactions during the treatment of the two groups was observed.Results： The total effective rate（95.24%）of the study group was higher than that（82.54%） of the control group（P〈0.05）.There were no significant differences in FVC,FEV1 and FEV% in the two groups before treatment（P〉0.05）,the FVC,FEV1 and FEV% of the two groups were significantly increased after the treatment of 28 d,and the FVC,FEV1 and FEV% of the study group were higher than those of the control group（P〈0.05）.There were no significant differences in MDA and8-isoprostane between the two groups before treatment（P〉0.05）.The MDA and 8-isoprostane decreased significantly in the two groups after the treatment of 28 d（P〈0.05）,the MDA and 8-isoprostane of the study group were lower than those of the control group after the treatment of 28 d（P〈0.05）.The incidence of adverse reactions in the control group was 7.94%（5/63）,and the difference was not statistically significant compared with the 6.35%（4/63） of the study group（P〉0.05）.Conclusion： Eucalyptus can significantly improve the pulmonary function and oxidative stress in patients with AECOPD,with good clinical effect and low adverse reaction rate,which is worthy of clinical application.