氟西汀对急性脑梗死后抑郁患者神经功能缺损的影响分析

Effect of Fluoxetine on neurologic impairment in patients with post-acute cerebral infarction depression

目的 探讨氟西汀对急性脑梗死后抑郁患者神经功能缺损的影响. 方法 选取2016年我院收治的128例急性脑梗死后抑郁患者,按照随机数字表法将其分为两组（研究组64例和对照组64例）,对照组患者予以常规治疗,研究组患者在此基础上加用氟西汀,并比较不同组患者治疗前后汉密尔顿量表评分（HAMD）和神经功能缺损程度（NIHSS）,以及治疗后生活质量评分. 结果 治疗前,研究组患者HAMD和NIHSS评分与对照组比较相近（P＞0.05）,治疗后,研究组患者HAMD和NIHSS评分分别为（14.7±3.0）分、（11.2±2.5）分,对照组分别为（17.3±2.5）分、（13.5±2.0）分,与治疗前相比均降低（均P＜0.05）,其中研究组患者HAMD和NIHSS评分降低更为明显（t=-5.326,-5.747;P＜0.05）;研究组患者脑卒中影响量表评分（SIS）总体生活质量评分为（1 126.0±164.5）,高于对照组（1 024.8±143.2）（t=-3.172,P＜0.05）;研究组患者服用氟西汀后未见严重不良反应发生. 结论 氟西汀不仅有助于改善老年急性脑梗死患者抑郁程度,同时还能促进其神经功能恢复,改善生活质量,值得推广借鉴。

Objective To investigate the effect of Fluoxetine on neurologic impairment in patients with depression following acute cerebral infarction.Methods A total of 128 patients with post-acute cerebral infarction depression admitted to our hospital in 2016 were randomized into two groups（64 in the study group and 64 in the control group）.Patients in the control group received routine treatment,and Fluoxetine was added in the study group.Post-treatment quality of life scores,Hamilton rating scale for depression（HAMD） scores and National Institutes of Health Stroke Scale （NIHSS） scores before and after treatment were compared between the groups.Results Before treatment,HAMD and NIHSS scores between the groups were not significantly different （all P 〉0.05）.After treatment,HAMD and NIHSS scores were 14.7 ± 3.0 and 11.2 ± 2.5,respectively,for the study group,and 17.3 ± 2.5 and 13.5 ± 2.0,respectively,for the control group,which were significantly lower than those before treatment in both groups（all P〈0.05）.The HAMD and NIHSS scores of the study group were significantly lower than those of the control group （t =-5.326,-5.747;all P 〈 0.05）;the overall quality of life score of the stroke impact scale （SIS） in the study group （1 126.0±164.5）was significantly higher than that in the control group （1 024.8 ±143.2）（t=-3.172,P 〈 0.05）;no serious adverse reactions occurred in the study group.Conclusions Fluoxetine can not only help to relieve depression in elderly patients with acute cerebral infarction,but also promote the recovery of neurological function and improve prognosis and quality of life.