2016上半年住院患者鲍曼不动杆菌耐药情况及用药研究

Study on the drug resistance and drug use of Acinetobacter baumannii in hospitalized patients in the first half of 2016

目的分析鲍曼不动杆菌耐药发生与年龄、住院天数、住院次数、基础疾病、抗生素使用等方面的相关性,为临床防治鲍曼不动杆菌感染用药提供参考。方法收集2016年1~6月间在北京友谊医院住院并出现鲍曼不动杆菌感染的患者133例。记录其年龄、性别、住院天数、住院次数、基础病因、抗生素使用情况等,分析鲍曼不动杆菌耐药发生与患者年龄、基础病因、用药情况等的相关性。结果 133例纳入患者平均年龄69.38岁,均对头孢唑啉耐药(100.00%);其次为呋喃妥因128例(96.24%)与氨苄西林108例(81.20%);其中37例(27.82%)纳入患者仅采用单一的抗生素进行治疗,治愈率为51.35%;94例(70.68%)纳入患者采用两种及两种以上的抗生素进行联合治疗,治愈率为26.32%。结论抗生素联用与否无统计学差异。

Objective To analyze the correlation between the occurrence of drug resistance of Acinetobacter baumannii and the age, length of hospital stay, the time of hospitalization, basic diseases, and the use of antibiotics, in order to provide reference for clinical prevention and treatment of Acinetobacter baumannii infection. Methods A total of 133 patients with Acinetobacter baumannii infection in Beijing Friendship Hospital from January 2016 to June 2016 were collected. The age, sex, days of hospitalization, the time of hospitalization, basic causes, antibiotic use, etc. were recorded. The correlation between drug resistance of Acinetobacter baumannii and the patient＇s age, basic etiology, and medication status was analyzed. Results 133 patients included in the study with the average age of 69.38 years old were all resistant to cefazolin （100.00%）, followed by nitrofurantoin in 128 cases （96.24%） and ampicillin in 108 cases （81.20%）. Among them, 37 cases （27.82%） were treated with only a single antibiotic, and the cure rate was 51.35%. 94（70.68%） patients were treated with the combination of two or more antibiotics for the treatment, and the cure rate was 26.32%.Conclusion There is no statistical difference between combined antibiotics and non-combined antibiotics.