天麻熄风汤联合奥卡西平对癫痫部分性发作患者NSE、S-100β、GFAP及脑电图的影响

Influence of Tianma Xifeng Decoction(天麻熄风汤) Combined with Oxcarbazepine on Serum NSE, S-100β, GFAP Levels and Electroencephalogram Parameters in Patients with Partial Seizure of Epilepsy

目的:观察天麻熄风汤联合奥卡西平对癫痫部分性发作患者血清神经元特异性烯醇化酶(NSE)、S-100β蛋白、胶质纤维酸性蛋白(GFAP)水平及脑电图各参数的影响。方法:将124例癫痫部分性发作患者随机分为对照组和治疗组,每组62例。对照组应用奥卡西平治疗,治疗组应用天麻熄风汤联合奥卡西平治疗,两组均持续治疗3个月。比较两组治疗后临床疗效和脑电图疗效,以及治疗前后血清NSE、S-100β和GFAP水平,脑电图4个频段的功率比值,认知功能和生活质量评分。结果:治疗组临床疗效总有效率高于对照组(P<0.05)。治疗后,两组血清NSE、S-100β和GFAP水平均低于治疗前(P<0.05),且治疗组均低于对照组(P<0.05);两组β、α和δ相对功率与治疗前比较,差异无统计学意义(P>0.05),两组θ相对功率高于治疗前(P<0.05),且治疗组高于对照组(P<0.05);治疗组脑电图明显好转率高于对照组(P<0.05);两组认知功能和生活质量评分均高于治疗前(P<0.05),且治疗组高于对照组(P<0.05)。结论:天麻熄风汤联合奥卡西平治疗癫痫部分性发作,能明显降低血清NSE、S-100β和GFAP水平,改善脑电图。

Objective： To observe the influence of Tianma Xifeng decoction combined with oxcarbazepine on serum neuron specific enolase （NSE）, S-100β protein, glial fibrillary acidic protein （GFAP） levels and Electroen- cephalogram （EEG） parameters in patients with partial seizure of epilepsy. Methods： A total of 124 patients with partial seizure of epilepsy were divided into two groups randomly. The control group with 62 cases were given oxcarbazepine treatment, and the treatment group were given Tianma Xifeng decoction combined with oxcar- bazepine treatment. Both groups were treated for 3 months. The clinical efficacy and the results of brain electro- gram evaluation after treatment were compared. Serum NSE, S-100β, GFAP levels and the power ratio of the four frequency bands of an electroencephalogram were detected. Likewise, cognitive function and quality of life scores were recorded before and after treatment in the two groups. Results： After treatment, total effective rate of the treatment group was significantly higher than that of the control group （P〈0.05）. Serum NSE, S-100β, GFAP levels were significantly decreased after treatment （P〈0.05）, of which the treatment group was significantly lower than those of the control group （P〈0.05）. The relative power of β,α and δ were not statistically significant compared with that before treatment （P〉0.05）. Relative power of θ was significantly increased after treatment （P〈 0.05）, of which the treatment group was significantly higher than those of the control group （P〈0.05）. The im- provement rate of EEG in the treatment group was significantly higher than that in the control group （P〈0.05）. Cognitive function and quality of life scores were significantly increased after treatment （P〈0.05）, of which the treatment group was significantly higher than those of the control group （P〈0.05）. Conclusion： Tianma Xifeng de- coction combined with oxcarbazepine can be used for patients with partial seizure of epilepsy, partly by reducing the levels of serum NSE, S-100β, GFAP levels and improve EGG.