兰索拉唑联合奥曲肽治疗急性非静脉曲张性上消化道出血的临床效果及安全性分析

Analysis of the Clinical Efficacy and Safety of Lansoprazole Combined with Octreotide in the Treatment of Acute Non Variceal Upper Gastrointestinal Bleeding

目的:探讨兰索拉唑联合奥曲肽治疗急性非静脉曲张性上消化道出血的临床疗效以及安全性。方法:选取自2014年1月到2017年1月我院收治的急性非静脉曲张性上消化道出血患者102例,随机分为A组、B组和C组,每组各34例。A组使用兰索拉唑进行治疗,B组使用奥曲肽进行治疗,C组联合使用兰索拉唑和奥曲肽进行治疗。对比三组患者的临床疗效、止血时间、血压稳定时间、胃管引流量、胃液PH值以及不良反应的发生情况。结果:治疗后,C组的显效率为61.76%,显著高于A组和B组(均P<0.05);C组的总有效率为97.06%,显著高于B组(P<0.05);C组的止血时间为(15.37±4.38)h,血压稳定时间为(7.23±1.18)h,胃管引流量为(236.59±29.81)mL,均显著少于A组和B组,而胃液PH值为(5.91±0.57),显著高于A组和B组(均P<0.05)。三组患者不良反应发生率的对比差异均没有统计学意义(P>0.05)。结论:兰索拉唑联合奥曲肽治疗急性非静脉曲张性上消化道出血可显著提高止血效果,临床疗效明显优于单用兰索拉唑或奥曲肽治疗,且安全性相当。

Objective： To analyze the clinical efficacy and safety of lansoprazole combined with octreotide in the treatment of acute non variceal upper gastrointestinal bleeding. Methods： 102 cases of patients with acute non-variceal upper gastrointestinal bleeding treated in our hospital from January 2014 to January 2017 were selected and randomly divided into group A, group B and group C, 34 cases in each group. Group A was treated with lansoprazole, group B was treated with octreotide, and group C was treated with lansoprazole and octreotide. The clinical efficacy, hemostasis time, blood pressure stability time, volume of gastric drainage, PH value of gastric fluid and incidence of adverse reactions were compared between the three groups. Results： After treatment, the apparent effective rate of group C was 61.76%, which was significantly higher than that of group A and group B（P〈0.05）. The total effective rate of group C was97.06%, which was significantly higher than that of group B（P〈0.05）. The hemostasis time of group C was（15.37±4.38） h, the blood pressure stability time was（7.23±1.18） h, the volume of gastric drainage was（236.59 ± 29.81） mL, which were significantly lower than those of group A and group B. The PH value of gastric fluid of group C was（5.91±0.57）, which was significantly higher than that of group A and group B（P〈0.05）. The incidence of adverse reactions of three groups showed no statistically significant difference（P〉0.05）.Conclusion： Lansoprazole combined with octreotide could significantly improve the hemostatic effect in the treatment of acute non variceal upper gastrointestinal bleeding. The clinical effect is much better than the single use of lansoprazole or octreotide, and the safety is quite.