非酒精性脂肪性肝病患者血清TNF-α、IL-6及LPS水平的表达及临床意义

Nonalcoholic Fatty Liver Disease: Expression and Clinical Significance of Serum TNF-α, IL-6 and LPS Levels

目的:探讨非酒精性脂肪性肝病(NAFLD)患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、脂多糖(LPS)的表达及其与胰岛素抵抗(IR)的关系。方法:选取2015年1月到2017年10月在我院接受治疗的NAFLD患者100例作为观察组,另选取同期在我院体检的健康志愿者50例作为对照组,比较两组受试者的空腹血糖(FBG)和空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)以及TNF-α、IL-6、LPS水平,采用Pearson相关系数分析TNF-α、IL-6、LPS与FBG、FINS、HOMA-IR之间的相关性。结果:观察组的FBG、FINS水平及HOMA-IR均明显高于对照组,存在统计学差异(P<0.05)。观察组的TNF-α、IL-6、LPS水平均明显高于对照组,存在统计学差异(P<0.05)。经Pearson相关分析显示,TNF-α、IL-6、LPS与FBG无相关性(P>0.05),与FINS、HOMA-IR均呈正相关(P<0.05)。结论:NAFLD患者存在明显的IR现象,且其血清中的TNF-α、IL-6、LPS水平明显上升,同时TNF-α、IL-6、LPS与IR呈正相关,并与NAFLD的发生、发展密切相关。

Objective： To investigate the expression of serum tumor necrosis factor（TNF-α）, interleukin-6（IL-6） and lipopolysaccharide（LPS） in patients with non-alcoholic fatty liver disease（NAFLD） and their relationship with insulin resistance（IR）. Methods： A total of 100 patients with NAFLD, who were treated in the First People＇s Hospital of Qinzhou from January 2015 to October 2017, were selected as observation group. Another 50 healthy volunteers who were examined in our hospital in the same period were selected as control group. The levels of fasting blood glucose（FBG）, fasting insulin（FINS）, insulin resistance index（HOMA-IR） and TNF-α, IL-6 and LPS were compared between the two groups. The correlation between TNF-α, IL-6, LPS and FBG, FINS, HOMA-IR was analyzed by Pearson correlation coefficient. Results： The levels of FBG, FINS and HOMA-IR in the observation group were significantly higher than those in the control group, and there was a statistical difference（P〈0.05）. The levels of TNF-α, IL-6 and LPS in the observation group were significantly higher than those in the control group,and there was a statistical difference（P〈0.05）. Pearson correlation analysis showed that TNF-α, IL-6 and LPS were not related to FBG（P〉0.05）, and were positively correlated with FINS and HOMA-IR（P〈0.05）.Conclusion： NAFLD patients have obvious IR, and the levels of TNF-α, IL-6 and LPS in the serum are significantly increased. TNF-α,IL-6 and LPS are positively correlated with IR, which are closely related to the occurrence and development of NAFLD.