腹腔穿刺中心静脉导管引流联合腹腔内药物灌注治疗肝硬化失代偿期腹水的临床观察

Clinical effect of peritoneal puncture drainage by central venous catheter combined with peritoneal perfusion of drugs for the treatment of cirrhotic ascites patients in decompensation period

目的观察研究腹腔穿刺中心静脉导管引流联合腹腔内药物灌注治疗肝硬化失代偿期腹水的临床效果。方法 120例失代偿期肝硬化腹水患者,按照随机数字表法分为观察组和对照组,各60例。两组基础治疗相同,定期监测肝肾功能、电解质、彩超等。观察组采用腹腔穿刺中心静脉导管引流联合腹腔内药物灌注治疗;对照组采用口服利尿剂、饮食保肝等支持治疗。治疗2周后,比较两组临床疗效。结果治疗2周后,观察组总有效率96.67%明显高于对照组的85.00%,差异具有统计学意义(P<0.05)。结论腹腔穿刺中心静脉导管引流联合腹腔内药物灌注治疗肝硬化失代偿期腹水,具有微创、安全、高效等优点,值得借鉴。

Objective To observe the clinical effect of peritoneal puncture drainage by central venous catheter combined with peritoneal perfusion of drugs for the treatment of cirrhotic ascites patients in decompensation period. Methods A total of 120 patients with cirrhotic ascites in decompensation period were divided into observation group and control group according to random number table method, 60 cases in each group. All patients were given basic treatment, the liver and kidney function, electrolytes, color Doppler ultrasound and so on were monitored regularly. The observation group was given peritoneal puncture drainage by central venous catheter combined with peritoneal perfusion of drugs treament, the control group was given oral diuretic, diet protection and other supportive treatment. The clinical effect of two groups after 2 weeks of treatment was compared. Results After 2 weeks of treatment, the total effective rate of the observation group was 96.67%, which was significantly higher than 85.00% of the control group, the difference was statistically significant（P〈0.05）. Conclusion Peritoneal puncture drainage by central venous catheter combined with peritoneal perfusion of drugs for the treatment of cirrhotic ascites patients in decompensation period has the advantages of minimally invasive, safe and efficient, is worthy of reference.