临床药师对抗生素相关性腹泻干预的效果分析

Pharmaceutical intervention in prevention and treatment of antibiotic-associated diarrhea

目的:探讨临床药师的干预对抗生素相关性腹泻发生的影响。方法:分析中国人民解放军总医院神经外科1年期间临床药师干预前后抗生素相关腹泻发生情况的差异,包括干预前后抗生素相关性腹泻的发生率、腹泻类型及相关因素等。结果:抗生素相关性腹泻与应用广谱抗菌药物的种类、疗程、患者年龄等关系密切。临床药师干预后,发生抗生素相关性腹泻的住院患者从干预前的52例(8.0%)降低至22例(3.3%)。结论:临床药师的干预能够减少抗生素相关性腹泻的发生。

Objective： To investigate the effect of pharmaceutical intervention in prevention and treatment of antibiotic-associated diarrhea（AAD）. Methods ： Analyze the differences of AAD before and after the intervention of clinical pharmacists in a major hospital. The incidence. diarrhea type and related factors of AAD among the patients in a neurosurgery department were collected and analyzed Results ： A total of 74 patients with AAD were collected with 52 pre-clinical pharmacist＇s intervention and 22 post-interventions. AAD was closely related to the application of broadspectrum antimicrobial agents, the course of treatment and the age of patients. The rate of AAD was reduced after clinical pharmacist＇s intervention. Conclusion ： Pharmaceutical intervention can reduce the incidence of AAD.